谷胱苷肽转移酶-π在卵巢上皮性肿瘤中的表达  

The Expression of GST-π in the Ascending Tumor.

作　　者：周莉莉[1] 梁宏峰[1] 丁杰[2] 

机构地区：[1]黑龙江省医院,哈尔滨市150036 [2]黑龙江省戒毒中心,哈尔滨市150030

出　　处：《中国初级卫生保健》2003年第9期79-80,共2页Chinese Primary Health Care

摘　　要：目的 研究谷胱苷肽转移酶-π(GST-π)与卵巢上皮性肿瘤发生与预后的关系。方法 通过免疫组化方法用谷胱苷肽转移酶(GST)单克隆抗体检测卵巢肿瘤73份(其中良性肿瘤20份、恶性肿瘤53份)中GST-π的表达。结果①GST-π恶性肿瘤的表达率高于在良性肿瘤中的表达率,差异具有显著性。②GST-π在不同病理类型的恶性肿瘤中的表达率无显著性差异。③GST-π在恶性肿瘤WHO分级1级和3级间差异无显著性,在临床分期Ⅰ～Ⅱ期和Ⅲ期～Ⅳ期间差异无显著性。结论 GST-π的过度表达可能与卵巢上皮性肿瘤的发生有关,对于卵巢恶性肿瘤的早期诊断具有一定意义,且GST-π的表达与临床分期及组织学分型均无明显相关性。OBJECTIVE To study the relationship between GST-π and current or prognosis of epithelial ovarian neoplasm. METHODS We analyzed the expression of GST-π neoclassic ovarian tissues(73 cases) by immunohisto chemistry. RESULTS (1) GST-π was higher in malignant tissue than in benign tissue. It has significant difference.(2)The expression rate of GST-π hadn' t significant difference in different pathology style of malignant tissue. (3) The expression rate of GST-π in grade 1 and grade 3 and in domical stage Ⅰ-Ⅱ and Ⅲ - Ⅳ without significant difference. CONCLUSIONS The excessive expression of GST-πmaybe played key roles in the currency of epithelium ovarian neoplasm, and had significance in the early diagnose. GST-IT has no significant relations with clinical to staging and differentiations.

关 键 词：谷胱苷肽转移酶-π 卵巢上皮性肿瘤 表达 预后 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]