铝与血管性痴呆发病机制的相关性探讨(英文)  

Correlation between aluminium and the pathogenesis of vascular dementia

作　　者：张桂青[1] 杨建霞[1] 仇银全[1] 陈湛愔[1] 胡浴桓[1] 浦忠才[2] 

机构地区：[1]石河子大学医学院第一附属医院医学心理研究所,新疆维吾尔自治区石河子市832008 [2]无锡市第二人民医院神经科,江苏省无锡市214002

出　　处：《中国临床康复》2003年第22期3054-3055,共2页Chinese Journal of Clinical Rehabilitation

基　　金：石河子大学科研基金资助(98-122227)~~

摘　　要：目的对缺血性脑卒中(不论有无痴呆)患者进行脑脊液(CSF)中铝含量进行测定,探索老年性痴呆的发病机制。方法观察组为缺血性脑卒中患者,对照组为整形外科患者。取两组患者的CSF,用原子吸收光谱进行CSF的铝含量测定,然后用韦氏智力量表及长谷川简易量表对患者智能进行测定。结果第1次检测结果:观察组铝含量为(81.6±8.9)ng/L,对照组为(35.6±2.2)ng/L(t=35.17,P<0.001)。第2次检测结果:观察组铝含量为(76.8±6.7)ng/L,韦氏成人智力量表均值低于75分,智力水平低于平常水平。对照组25例,铝含量为(14.0±1.2)ng/L(t=34.55,P<0.001)。第3次检测结果:观察组铝含量为(100.6±7.8)ng/L,长谷川简易量表均值为10.48分,为中等以下痴呆。对照组铝含量为(32.3±0.1)ng/L(t=14.92,P<0.001)。3次检测结果中观察组患者的铝含量均较对照组增加。结论VD及AD可能有相同的致病原因,中枢神经系统铝中毒。AIM:To study the va sc ular dementia(VD)by determination of aluminium(Al )in cerebrospinal fluid(C SF),and explore pathogenesis of VD from Al intoxication.METHODS:Observation group of vascular disease patients the Al content in CSF were compared with th e control group of via plastic patients withou t nervous system damage.Determi nate the Al content in CSF by the atomic absorption spectrum with the were le ng th of 309.3nm.Three investigatio n were performed.RESULTS:There were sig nificant differences between VD and control group of Al in CSF(P<0.001) .VD group were higher than control group.

关 键 词：铝 血管性痴呆 发病机制 脑脊液 含量测定 

分 类 号：R749.13[医药卫生—神经病学与精神病学] R446.14[医药卫生—临床医学]