135例鼻咽癌患者放射治疗后影响远期预后的因素分析  

Prognostic Factors of 135 Nasopharyngeal Carcinoma Patients Treated With Radiotherapy

作　　者：袁君[1] 魏瑞[1] 章正[1] 

机构地区：[1]中南大学湘雅医院放疗科,湖南长沙410008

出　　处：《中国医师杂志》2003年第9期1208-1209,共2页Journal of Chinese Physician

摘　　要：目的　探讨影响鼻咽癌患者放射治疗后远期预后的因素。方法　选择首诊的鼻咽癌患者 13 5例 ,均予以根治性放射治疗 (放疗 ) ,照射剂量 68～ 80Gy/7～ 8周。分析 13项可能对鼻咽癌预后产生影响的因素 ,利用统计软件进行单因素及Cox回归模型多因素分析。结果　鼻咽癌 10年生存率为 48 9% ;在单因素分析的 13项中有 8项因素影响鼻咽癌的预后 (P <0 0 5 ) ;而多因素分析中仅有颅神经损伤、颅底骨质破坏及N分期为影响鼻咽癌独立的预后因素。结论　鼻咽癌伴有颅神经损伤和 /或颅底骨质破坏和 /或颈部较大肿块者预后不良 ,对此类病例需进行综合治疗 ,以减少肿瘤的复发及转移 。Objective To analyze the prognostic factors of nasopharyngeal carcinoma treated with radiotherapy.Methods 135 preliminary diagnosed patients were selected and treated with radiotherapy to a total dose of 68～80 Gy in 7～8 weeks. In order to analyze the factors affecting prognosis of NPC,SPSS analysis and Cox regression analysis were used to identify the prognostic factors.Results The overall 10-year survival rate was 48 9%; Univariate analysis suggested that 8 out of 13 items were significant factors for prognosis (P<0 05). Multiple factors analysis suggested that only cranial nerve palsy ,skull base invasion and N stage were significant factors for prognosis.Conclusions Prognosis of patients with cranial nerve palsy and/or skull base invasion and /or bigger cervical tumor is poor.Comprehensive treatment may reduce relapse and metastasis and improve the patient's survival.

关 键 词：鼻咽肿瘤 放射治疗 预后 统计学 

分 类 号：R739.63[医药卫生—肿瘤]