94例无淋巴结转移乳腺癌MVD、Neu基因及ER的表达及预后的相关性研究  

Study of the Relationship Among MVD,the Expression of Neu Gene and Estrogen Receptor and Prognosis in 94 Cases of Early Breast Cancer

作　　者：杨昆宪[1] 迟昆萍[1] 贾玲[1] 李琳[1] 纳智明[1] 陈居敏[1] 

机构地区：[1]云南省第一人民医院肿瘤科,云南昆明650032

出　　处：《中国医师杂志》2003年第9期1210-1211,共2页Journal of Chinese Physician

摘　　要：目的　探讨微血管密度 (MVD)、癌基因 (c -erbB -2 /Neu)及雌激素受体 (ER)在无淋巴结转移乳腺癌患者的表达及与预后的关系。方法　选择经手术根治的无淋巴结转移乳腺癌患者 94例 ,检测手术根治后标本中MVD、Neu基因及ER。结果　 94例患者MVD 3 5 4± 9 8,Neu基因阳性表达为 44 % ( 4 1/94) ,ER阳性表达为 61% ( 5 8/94)。本组病例 3年内复发 16例 ,复发者其MVD 42 5± 10 6明显高于未复发者 3 1 4± 8 7,P <0 0 5 ,有显著性差异 ;且复发者Neu基因均为阳性表达 ,ER阳性 5例。MVD、Neu基因及ER与复发的关系经直线相关分析提示为 (γ =0 745 ,0 867,P <0 0 1和γ =0 186,P >0 0 5 )。讨论　淋巴结有无转移通常被认为是判断乳腺癌预后的一个重要因素 ,然而淋巴结无转移者仍有部分患者在手术根治后出现复发转移 ,本研究提示MVD、Neu基因是判断无腋淋巴结转移乳腺癌患者预后的重要指标 。Objective To investigate the relationship among microvessel density (MVD),the expressions of Neu gene and estrogen receptor(ER) and prognosis in early breast cancer.Methods MVD,the expression of Neu gene and ER was examined in radical operation samples from 94 cases of breast cancer without lymphatic metastatis.Results The MVD, expression of Neu gene and ER in 94 cases of early breast cancer were 35 4±9 8,44 percent(41/94),61 percent (58/94)respectively;Three years after operation,16 cases had relapse in 94 cases of early breast cancer. The MVD of the relapse cases were 42 5±10 6, which was higher than that of non-relapse,whose MVD was 31 4±8 7,there was obvious difference(P<0 05).The Neu gene expression of all relapse cases was positive;Meanwhile,the positive expression of ER only has 5 cases in the relapse.The correlation between relapse and MVD,Neu gene expression was obvious(γ=0 745,0 867,P<0 01),but there was no correlation between relapse and ER expression(γ=0 186,P>0 05).Conclusions Whether there is a lymphoglandula metastasis is an important factor in evaluating prognosis of breast cancer.After radical operation there still are partly replase case in the breast cancer without lymphoglandula metastasis.MVD and Neu gene expression are important factors to estimate prognosis of the early breast cancer.Breast cancer which has higher MVD and Neu gene expression has worse prognosis than that of lower MVD and negative Neu gene expression. [

关 键 词：早期乳腺癌 MVD NEU基因 ER 预后 

分 类 号：R737.9[医药卫生—肿瘤]