化疗加放疗对乳腺癌脑转移的疗效观察  

Curative Effects on Mammary Cancer Transferred to Brain Treated by Chemotherapy and Radiation

作　　者：张忠山[1] 李国亮[1] 赵新华[1] 谢开红[1] 周妍[1] 周意华[1] 

机构地区：[1]郴州医专附院肿瘤科,湖南郴州423000

出　　处：《郴州医学高等专科学校学报》2003年第3期15-17,共3页

摘　　要：目的　观察化疗加放疗对乳腺癌脑转移的疗效。方法　 92例经CT、MRT确诊乳腺癌脑转移的病例 ,随机分成治疗组 (放疗加化疗 )和对照组 (单纯放疗 ) ,各 4 6例。对照组治疗方案为DT 4 0Gy 4周 ,部分单发病灶增加 10 -2 0Gy 1- 2周 ,治疗组 4 6例在对照组的基础上加用“CAF”方案化疗。结果　对照组 1年和 2年生存率分别为 15 .2 %和6 .5 % ,治疗组则分别为 4 5 .6 %和 19.5 %。两组一年生存率有显著差异性 (P <0 .0 5 ) ,2年生存率无显著差异性。两组患者不良反应无显著性差异性 (P >0 .0 5 )。脑单发病灶和多发病灶患者的 2年生存率为 2 9%和 3.4 % ,具显著差异性(P <0 .0 5 )。结论　放疗加化疗综合治疗对乳腺癌脑转移有较好疗效 ,且能耐受 ,对脑部单发转移疗效好于多发转移。Objective To observe the curative effects on mammary cancer transferred to brain treated by chemotherapy and radiation. Methods 92 cases with the above disease were divided into two groups randomly -treatmnt group adopting chemotherapy and radiation and control group using radiation with each group 46 cases. The treatment plan for the control group was DT 40Gy/4 week and 10-20 Gy/1-2 week was added to parts of solitary focus , In the treatment group CAF chemotherapy was used on the basis of plan of the control group . Results The survival rate of one year and two years in control group was 15.2% and 6.5% respectively in treatment group 45.6% and 19.5% respectively . There was a significant difference in the survival rate of one year between the two groups(p<0.005) but not the the survival rate of two years. Conclusions It has good effects to treat mammary cancer transferred to brain with the comprehensive treatment of chemotherapy and radiation.

关 键 词：乳腺癌 脑转移癌 放疗 综合治疗 

分 类 号：R737.9[医药卫生—肿瘤]