左肺逆循环伴双向腔肺吻合术的动物模型建立  

Establish the Reversal Model of Left Lung Blood Flow with Bidirectional Cavopulmonary Anastomosis in Canines

作　　者：张海波[1] 陈会文[1] 苏肇伉[1] 丁文祥[1] 

机构地区：[1]上海第二医科大学附属新华医院上海儿童医学中心心胸外科,上海200092

出　　处：《上海实验动物科学》2003年第3期139-142,共4页Shanghai Laboratory Animal Science

摘　　要：为临床提供实验手术基础,以期拓宽复杂先心的手术适应症,建立了左肺逆循环与双向腔肺吻合术相结合的动物模型,将犬左心耳与左肺动脉远心端吻合;桥接管道连接左肺动脉近心端与左肺静脉;将上腔静脉与右肺动脉吻合,实现左肺逆循环与双向腔肺吻合。6头实验犬均存活3d以上,彩超及血管造影检查显示吻合口血流通畅,上腔静脉回流血及左肺逆行血流行进良好。结果提示,左肺逆循环伴双向腔肺吻合手术切实可行,且可进一步向全腔肺吻合术过渡;本实验为今后拓展复杂先心合并过高肺动脉压力患儿手术治疗的适应症提供了实验基础。To provide a series studies for influence of the left lung inverse circulation and BCPA on pulmonary physiology and function and probably to use this technique to treat the patients with functional single ventricle with pulmonary hypertension, the reversal model of left pulmonary circulation (RLPC) with bidirectional cavopulmonary anastomosis (BCPA) was established in canines. Six mongrel dogs were chosen to be studied on this model. The procedure of establishing RLPC plus BCPA include anastomose the distal end of left pulmonary artery (LPA) to the left auricle; use a graft tube to connect the proximal LPA to three pulmonary veins and do a end to side anastomosis between supra vena cava and right pulmonary artery. All canines were survived over three days. Echo and angiography showed that there were no remarkable obstruction in left lung inverse circulation and cavopulmonary anastomosis. So the RLPC plus BCPA is technically feasible, it affords a experimental model for in vivo study of pulmonary pathophysiology and haemodynamics in complex congenital heart diseases kids with pulmonary hypertention and it's a interm palliation and can be transit to total cavapulmonary shunts.

关 键 词：动物模型 肺动脉高压 左肺逆循环 双向腔肺吻合 全腔肺吻合 心脏病 

分 类 号：R-332[医药卫生]