恶劣心境与5-HTT,ACE基因多态性相关性研究  

POLYMORPHISMS OF SEROTONIN TRANSPORTER AND ANGIOTENSIN CONVERTING ENZYME GENE IN DYSTHYMIC DISORDER

作　　者：尤劲松[1] 胡随瑜[1] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,长沙410008

出　　处：《中国现代医学杂志》2003年第18期43-45,共3页China Journal of Modern Medicine

基　　金：国家自然科学基金资助项目 ( 3 0 0 70 95 3 )

摘　　要：目的 :探讨恶劣心境患者与五羟色胺转运体 (5 -HTT)基因和血管紧张素转换酶 (ACE)基因的三种多态性的相关性。方法 :运用多聚酶链式反应技术 (PCR)检测 35例恶劣心境患者与 90例健康对照者三种基因多态性的分布频率。结果 :恶劣心境患者与健康人中 5 -HTTLPR基因型和等位基因构成比均存在显著差异(P <0 .0 5 ,P <0 .0 1) ,恶劣心境患者的SS基因型和S等位基因频率明显高于健康人组。结论 :5 -HTTLPR为SS基因型的人群可能易患恶劣心境障碍。Objective:To study the relationship between dysthymic disorder and polymorphisms of serotonin transporter (5-HTT) and angiotensin converting enzyme (ACE) gene. Methods:Allelic variation of 5-HTT and ACE in thirty-five patients and ninety control sybjects were determined using a polymerase chain reaction-based technique.Results:The frequency of serotonin transporter gene-linked functional polymorphic region (5-HTTLPR) short/short(SS) genotype and S allele were significantly higher in dysthymic disorder patients than in control subjects. Conclusions:The presence of 5-HTTLPR short allele may increase the risk of dysthymic disorder.

关 键 词：恶劣心境 基因 多态性 五羟色胺转运体 血管紧张素转换酶 

分 类 号：R749.5[医药卫生—神经病学与精神病学]