颈中交感神经节阻滞治疗偏头痛及与血清C反应蛋白的关系  

THE CLINICAL EFFECT OF MIDDLE CERVICAL GANGLION BLOCK THERAPY IN PATIENTS WITH MIGRAINE AND ITS RELATION TO SERUM C-REACTIVE PROTEIN

作　　者：李英杰[1] 贾和平[1] 武小玲[1] 徐谦[1] 

机构地区：[1]河北省张家口市解放军第251医院神经内科,张家口075000

出　　处：《中国现代医学杂志》2003年第18期71-72,共2页China Journal of Modern Medicine

摘　　要：目的 :C -反应蛋白 (CRP)作为监测炎症反应的一种新的免疫指标 ,该文观察了颈中交感神经节阻滞治疗偏头痛的临床效果 ,并探讨其与血清C反应蛋白的关系。方法 :颈中交感神经节阻滞采用气管旁颈 6横突法 ,每日 1次 ,两侧交替阻滞 ,共 7次。采用散射比浊法测定 4 8例偏头痛患者治疗前后和 2 8例正常人血清CRP水平。结果 :偏头痛患者经颈中交感神经节阻滞后头痛次数减少、头痛时间明显缩短、程度减轻 ,与治疗前比较有显著性差异 (P <0 .0 1)。偏头痛患者血清CRP显著增高 (P <0 .0 1) ,颈中交感神经节阻滞后血清CRP恢复正常。结论 :偏头痛患者神经内分泌免疫调节网络可能存在一些障碍 ,颈中交感神经节阻滞可调节偏头痛患者的神经、内分泌及免疫功能。Objective:An elevated serum level of C-reactive protein(CRP),an inflammtory marker,provides a novel method for detecting inflammatory process. The purpose of this study was to observe the clinical effects of middle cervical ganglion block(MCGB) therapy in patients with migraine and investigate its relation to serum CRP.Methods:MCGB were made near the transvers process of C6, unilateral blockade by turns, 1 time injection everyday(7 injections in all), Curative effect were assessed after a month. Serum CRP was measured in 48 patients with migraine and 28 normal controls by nephelometry. Results:Compared with before treatment,the number of headache attack,duration and degree of headache were all reduced obviously(P<0.01).Serum CRP levels in migraine patients were notably increased in comparision with the controls( P<0.01), Serum CRP concentrations were return to normal levels.Conclusion:This suggests that the nerve-incretion-immunomodulation network may be some obstacle in patients with migraine,and MCGB may modulate its function.

关 键 词：偏头痛 颈中交感神经节 阻滞 C—反应蛋白 

分 类 号：R747.2[医药卫生—神经病学与精神病学]