芬太尼透皮贴剂治疗鼻咽癌晚期癌痛的疗效观察  

Transdermal fentanyl in preventing the cancer pain of advanced nasopharyngeal carcinoma

作　　者：高世霞[1] 梁桂玲[2] 李浩[1] 李培芹[1] 朱景英[1] 林翠风[1] 郭冬梅[1] 

机构地区：[1]山东省肿瘤医院,山东济南250617 [2]山东大学卫生部耳鼻喉科重点实验室

出　　处：《山东大学基础医学院学报》2003年第4期221-222,共2页Journal of Preclinical Medicine College of Shandong Medical University

摘　　要：目的 :观察芬太尼透皮贴剂治疗鼻咽癌癌痛的效果及其不良反应。方法 :鼻咽癌中、重度癌痛 4 0例使用芬太尼透皮贴剂。采用多中心随机开放实验 ,初始剂量 2 5 μg h或参照吗啡剂量折算确定剂量 ,3d更换 1次。根据疼痛情况调整剂量 ,直至镇痛满意。结果 :中度以上疼痛缓解率为 10 0 %,其中完全缓解6 2 .5 %,明显缓解 37.5 %。其主要不良反应有便秘、头晕、恶心、嗜睡、皮肤搔痒。未出现呼吸抑制等严重不良反应。结论 :芬太尼贴剂治疗鼻咽癌晚期癌痛疗效可靠。Objective: To investigate the efficacy , side effects of transdermal fentanyl system in preventing cancer pain of nasopharyngeal carcinoma. Methods: 40 patients with moderate or severe cancer pain of nasopharyngeal carcinoma were treated by transdermal fentanyl system. With multicenter random opening trial ,the initial dosage was 25μg/h or based on the conversion table of morphine dosage over fentanyl, it was changed every three days, and adjusted the dosage according to the pain intensity until painless or nearly painless. Results: The moderate or more relief rate was 100%, in which complete relief rate was 62.5% ,obvious relief rate was 37.5%.The main side effects was constipation, dizziness, nausea, lethargy, pruritus.Conclusion: The treatment effective of transdermal fentanyl system is reliabal in preventing cancer pain of advanced nasopharyngeal carcinoma.

关 键 词：芬太尼透皮贴剂 治疗 鼻咽癌 晚期 癌痛 疗效 临床观察 不良反应 

分 类 号：R739.6[医药卫生—肿瘤] R971.2[医药卫生—临床医学]