^(18)F-FDG hPET/CT显像与^(99)Tc^m-MDP骨显像探测骨转移瘤的价值  

Comparison of the clinical values of ^(18)F-FDG hPET/CT and ^(99)Tc^m-MDP bone scanning in detection of bone metastases

作　　者：韩丽君[1] 屈婉莹[1] 何洁[2] 李威[3] 李伟[1] 赵洪山[1] 

机构地区：[1]卫生部北京医院核医学科,100730 [2]首都医科大学附属宣武医院核医学科 [3]卫生部北京医院放射科,100730

出　　处：《中华核医学杂志》2003年第4期204-206,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的　探讨1 8F 脱氧葡萄糖 (FDG)hPET CT与99Tcm 亚甲基二膦酸盐 (MDP)骨显像探测骨转移瘤的临床价值。方法　临床拟诊恶性肿瘤或肿瘤术后复发合并骨病变患者 34例 ,均于 2周内分别行FDG和MDP骨显像 ,其中 31例经手术或活组织病理检查证实为原发肿瘤患者 ,余 3例为原发灶不明但广泛骨转移者。结果　 34例患者中 2 6例有骨转移 ,共探测到 75个骨病灶 ,其中骨转移灶 6 3个 ,良性病灶 12个 (其中骨退行性变 8个 ,肋骨骨折 2个 ,结核和慢性炎症各 1个 )。1 8F FDGhPET CT显像探测骨转移瘤灵敏度为 90 5 % ,特异性为 83 3% ,准确性为 89 3% ;99Tcm MDP骨显像分别为 79 4 % ,75 0 %和 78 7% (P均 >0 0 5 )。结论　99Tcm MDP骨显像仍为诊断骨转移瘤的首选方法 ,1 8F FDGhPET CT显像对鉴别诊断骨转移瘤具有一定临床价值。Objective To evaluate the usefulness of hPET/CT with 18F-2-fluorodeoxyglucose (FDG) for the detection of malignant bone metastases, and to compare FDG results with conventional 99Tcm-methylene diphosphonic acid (MDP) bone scan findings. Methods Thirty-four patients with biopsy-proven malignancy and suspected bone metastases underwent whole-body bone scanning and 18F-FDG hPET/CT imaging. Focal bone hPET and X-CT fusion imaging were performed in addilion to the positive whole-body bone scanning on 11 patients. Results 18F-FDG hPET/CT had a sensitivity of 90.5%, a specificity of 83.3% and an accuracy of 89.3% for diagnosis of bone metastases whereas the values for 99Tcm-MDP bone scanning were 79.4%, 75.0% and 78.7%, respectively(P>0.05). There is no significant difference between 18F-FDG hPET/CT and 99Tcm-MDP bone scanning for detecting bone metastases. Conclusion 99Tcm-MDP bone scanning has been usually used as the imaging modality of choice in the diagnosis of bone metastases, but 18F-FDG hPET/CT imaging is helpful in differentiation of bone metastases from benign lesions.

关 键 词：骨肿瘤 肿瘤转移 ^18F—FDGhPET CT ^99TC^M-MDP 放射性核显像 诊断 

分 类 号：R730.4[医药卫生—肿瘤]