^(18)F-FDG hPET/CT显像在腹部消化系肿瘤的应用  

Evaluation of abdominal digestive tumors with ^(18)F-FDG coincidence imaging

作　　者：李林法[1] 沈文华[1] 赵葵[1] 闻世凤[1] 罗旭光[1] 朱阳军[1] 程维荷[1] 

机构地区：[1]浙江大学医学院附属第一医院核医学科,杭州310003

出　　处：《中华核医学杂志》2003年第4期206-207,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的　评价1 8F 脱氧葡萄糖 (FDG)符合线路显像结合图像融合 (hPET CT)探测可疑腹部消化系恶性肿瘤或肿瘤复发的临床价值。方法　对 5 1例临床怀疑为腹部消化系恶性肿瘤或肿瘤复发患者行1 8F FDG符合线路显像 ,经迭代法处理和重建 ,获得经检查衰减校正后的断层图像和融合图像 ,以目测双盲阅片进行诊断分析 ,并与手术病理检查或CT和 (或 )MRI、临床随访作出的最后诊断结果进行对比。结果　1 8F FDG符合线路显像对腹部消化系肿瘤诊断的灵敏度、特异性和准确性分别为 94 1% ,76 5 %和 88 2 % ;对结直肠癌复发的诊断灵敏度为 94 1% ,特异性为 83 3% ,准确性为91 3%。结论　1 8F FDG符合线路显像对腹部消化系恶性肿瘤或肿瘤复发的诊断具有较高的灵敏度和准确性。Objective To evaluate the clinical usefulness of 18F-fluorodeoxyglucose (FDG) coincidence imaging in detecting suspected abdominal digestive tumors or recurrent cancer. Methods 51 patients with suspected abdominal digestive malignant tumors or recurrent cancer underwent 18F-FDG coincidence imaging using GE HAWKEYE coincidence SPECT at 40～60 min after the intravenous injection of 259～298 MBq 18F-FDG. The acquired data were reconstructed using iterative algorithm, attenuation-corrected using X ray and fused using CT. The images were interpretated visually by nuclear physician with double blindness. The results were also compared and assessed with the clinical diagnosis, histological examination CT and MRI findings. Results In all patients with suspected abdominal digestive malignant tumors, the sensitivity, specificity and accuracy of 18F-FDG coincidence imaging was 94.1%, 76.5% and 88.2% respectively. And in the patients with colorectal recurrent cancer, the sensitivity, specificity and accuracy were 94.1%, 83.3% and 91.3% respectively. Conclusion 18F-FDG coincidence imaging had highly sensitivity and accuracy in diagnosis of abdominal digestive malignant tumor or recurrent cancer.

关 键 词：腹部消化系肿瘤 ^18F—FDGhPET CT 诊断 放射性核素显像 

分 类 号：R735[医药卫生—肿瘤] R730.44[医药卫生—临床医学]