贫血与鼻咽癌放疗效果的相关性研究  

Correlative study on anemia and radiotherapy effects in nasopharyngeal carcinoma

作　　者：陈锦生[1] 江远仕[1] 曹锡标[1] 詹永忠[1] 杨立业[1] 陈建秀[1] 陈成武[1] 李杨[1] 

机构地区：[1]潮州市中心医院,广东521021

出　　处：《中华放射医学与防护杂志》2003年第4期265-267,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：广东省科委重点科技攻关项目 (97114 ) ;广东省卫生系统"五个一工程"重点专科基金资助项目 (96186)

摘　　要：目的　探讨血液携氧能力对鼻咽癌放疗效果的影响。方法　动态观察 16 1例鼻咽癌放疗前、放疗中、放疗后Hb、RBC、MCH、HCT、MCV、MCHC、RDW 7项指标变化 ,随访 5年以上 ,根据贫血情况进行分组 ,并讨论分析贫血与放疗效果、生存率之间的关系和机理。结果　全程无贫血病人与不同时期有不同程度贫血的病人在生存率上差异有显著性 (P <0 0 5 ) ,放疗前已有贫血 ,放疗中出现贫血或加重 ,都是直接影响放疗敏感性的重要因素。贫血程度越重 ,放疗效果越差。结论　贫血 低血红蛋白血症引起血液携氧能力下降可造成肿瘤细胞乏氧 ,从而使肿瘤细胞对射线抗拒 ,最终导致放疗效果明显降低 ,影响患者生存质量和生存率。Objective To study the effect of oxygen-carrying ability of blood efficacy of radiotherapy for patients with nasopharyngeal carcinoma. Methods Altogether 161 cases of patients with nasopharyngeal carcinoma were classified according to severity of anemia,and Hb,RBC,MCH,HCT,MCV,MCHC and RDW were tested before,during and after radiotherapy.The patients were followed-up for up to 5 years,the relationship and mechanism among anemia,radiotherapy effects and survival rate was discussed. Results The survival rate between anemia group and non-anemia group was different significantly ( P <0.05) . Anemia before radiotherapy,anemia appearance or anemia deterioration during radiotherapy were sensitive factors affecting radiotherapy results.The anemia more severe,the radiotherapy worse. Conclusion Anemia-hypohemoglobinemia leads to decrease of oxygen-carrying capacity of blood,resalting in oxygen deficiency of tumor cells and their radiotherapy resistance,Therefore this method is worthy of further studies.

关 键 词：贫血 鼻咽癌 放疗 相关性研究 血液携氧能力 

分 类 号：R739.63[医药卫生—肿瘤]