X刀分次治疗帕金森病的临床应用  

The clinical research on fractionated irradiation treatment with X knife in patients of PD

作　　者：韦鹏翔[1] 陈旭[1] 艾泉山[1] 夏吉勇[1] 杨炯达[2] 陈炳桓[2] 

机构地区：[1]北京友谊医院神经外科,100050 [2]北京天坛医院神经外科

出　　处：《中华放射医学与防护杂志》2003年第4期280-282,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：解放军科研基金资助项目 (2 0 0 0 ) ;吉林省卫生厅基金资助项目 (1998)

摘　　要：目的　探讨帕金森病 (PD)的X刀分次治疗方法 ,为PD找出一条可行的无创治疗途径。方法　 16例难治性PD病人 ,采用X刀 14 0Gy分 2次损毁丘脑腹外侧核中间部 (VIM)治疗 ;8例病人采用 16 5Gy分 3次损毁VIM核治疗 ;每次间隔 2 4h。结果　X刀治疗后 3～ 2 4个月随访 ,2 4例病人消除或改善了震颤症状 ;僵直或运动减少症状不同程度的缓解 ;无并发症发生。神经生理学检查无显著改善。结论　X刀分次损毁VIM核 ,可安全、无创治疗PD ;震颤症状改善显著。Objective To explore X knife treatment methods and to seek a new effective way for PD therapy. Methods Sixteen patients of PD were treated by performing VIM with 2 times of X knife fractionated irradiation (interval, 24 h) to a total dose of 140 Gy, and 8 patients of PD were treated by performing VIM with 3 times of X knife fractionated irradiation (interval, 24 h) to a total of dose of 165 Gy. Results During 3-24 months follow-up after X knife treatment, tremor was stopped in 19 patients and was relived significantly in 5 patients. Rigidity and bradykinesia of PD were relieved slightly. No complications were observed. Conclusion To perform VIM with X knife fractionated irradiation can be safely and effectively used to treat PD. The tremor of PD can be relieved slightly.

关 键 词：X刀分次治疗 帕金森病 临床应用 疗效观察 

分 类 号：R742.5[医药卫生—神经病学与精神病学]