4-羟基-3-羧基苯甲醛水杨酰腙及其配合物抑菌活性初步研究  

Studies on bacteriostasis activities of 3-carboxyl-4-hydroxybenzaldehyde salcyloyl hydrazone and their complexes

作　　者：马兴铭[1] 雒艳萍[1] 麻宝成[2] 杨汝栋[2] 

机构地区：[1]兰州医学院基础医学院免疫学教研室,730000 [2]兰州大学化学化工学院

出　　处：《兰州医学院学报》2003年第3期3-4,12,共3页Journal of Lanzhou Medical College

摘　　要：目的　研究配体 4-羟基 - 3 -羧基苯甲醛水杨酰腙 (H2 L)及其配合物的抑菌活性。方法　合成配体 4-羟基 - 3 -羧基苯甲醛水杨酰腙及其配合物 ,采用K -B法检测其对金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长抑制作用。结果　配体H2 L及其金属配合物能抑制金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长 ,形成抑菌环 ,尤其配体H2 L形成抑菌环直径最大。结论　配体H2 L及其金属配合物均有一定的抑菌作用 ,配体H2 L的抑菌作用最强。Objective To study bacteriostasis activities of 3-carboxyl-4-hydroxybenzaldehyde salcyloyl hydrazone(H 2L 4) and their complexes.Methods Ligand H 2L and their complexes were synthesized. The bacteriostasis activities of H 2L and their complexes in vitro were tested with K-B method. Results It is a dramatic bacteriostasis activity on Staphyloccus aureus, Escherichia coli, Bacillus subtilis. Ligand H 2L Bacteriostasis ring diameter is largest especially. Conclusions: Ligand H 2L and their complexes have bacteriostasis activity in vitro. Bacteriostasis activities of ligand H 2L are strong est .

关 键 词：4-羟基-3-羧基苯甲醛水杨酰腙 配体 抑菌活性 金黄色葡萄球菌 大肠埃希菌 枯草芽胞杆菌 

分 类 号：R978.1[医药卫生—药品]