老年期痴呆症患者自身抗胰岛素和抗髓鞘碱性蛋白抗体的研究  

Studies on serum autoantibodies to insulin and myelin basic protein in elderly patients with dementia

作　　者：王若菡[1] 陈俊杰[1] 何晓嫱[1] 刘智敏 陈建业[1] 熊泽宇[1] 葛炜[2] 程吟梅[2] 张曙云[2] 叶善龙 

机构地区：[1]四川大学华西医学中心生物化学与分子生物学研究所,成都市610041 [2]中国人民解放军杭州疗养院 [3]上海市长宁区老年痴呆专科医院

出　　处：《中华老年医学杂志》2003年第8期463-465,共3页Chinese Journal of Geriatrics

摘　　要：目的 探讨老年期痴呆症患者血清自身抗胰岛素和抗髓鞘碱性蛋白(MBP)抗体含量变化及其临床意义。方法 采用双夹心酶联免疫吸附定量测定法(ELISA)同步检测113例老年期痴呆症患者〔Alzheimer病(AD)74例和多发性梗塞性痴呆(MID)39例〕和66例老年健康人血清抗胰岛素和抗MBP抗体水平。结果 血清抗胰岛素抗体水平,AD组和MID组(1/A_(630)分别为1.30±0.16和1.34±0.14),高于健康组(1/A_(630)为1.10±0.10)(P<0.001);但血清抗MBP抗体水平,AD组和MID组(1/A_(630)分别为6.45±3.03和6.19±2.09)与健康组(1/A_(630)为6.88±2.73)的差异无统计学意义。结论 老年期痴呆症患者血清自身抗胰岛素抗体增高与其致病机制的关系值得深入研究。Objective To explore the changes of serum levels of autoantibodies to insulin and myelin basic protein (MBP) and their clinical significance to patients with senile dementia. Methods Serum autoantibodies to insulin and MBP were measured by ELISA in 113 cases of patients with dementia, including 74 Alzheimer's disease(AD) and 39 multi-infarct dementia(MID) , and 66 healthy age-matched subjects. Results The serum levels of autoantibodies to insulin were significantly higher in AD and MID groups (1/A630 1. 30± 0. 16 and 1. 34± 0. 14 respectively) than in the healthy group(l/A630l. 10± 0. 10,P<0. 001). But the serum autoantibodies to MBP in AD and MID groups (I/ A630 6. 45 ± 3. 03 and 6. 19 ± 2. 69) were not found statistically different from the healthy group(1/ A630 6. 88 ± 2. 73 ) . Conclusions The relationship between abnormal elevated levels of autoantibodies to insulin and pathogenesis of AD and MID patients merits further studies.

关 键 词：老年痴呆症 抗胰岛素抗体 抗髓鞘碱性蛋白 双夹心酶联免疫吸附定量测定法 

分 类 号：R749.16[医药卫生—神经病学与精神病学]