MAGE基因与恶性肿瘤  

Melanoma Antigen Genes (MAGE)and Malignant Tumors

作　　者：徐建中[1] 林山[1] 

机构地区：[1]浙江大学医学院附属第一医院耳鼻咽喉科，浙江杭州310006

出　　处：《癌症》2003年第9期1001-1004,共4页Chinese Journal of Cancer

摘　　要：MAGE基因在许多恶性肿瘤细胞中表达,其产物是一种肿瘤排斥抗原,能诱导细胞毒性T淋巴细胞(CTL)特异性识别和杀伤肿瘤细胞,在肿瘤免疫治疗中具有重要意义。本文就MAGE基因与肿瘤的关系作一综述。The melanoma antig en g enes (MAGE)were found to express in a variety of tumors of different hist olog ical orig in.Peptides encoded b y the MAGE g enes are tumor rejection antig ens ,which can induce specific cytot oxic T-lymphocytes (CTL)to recog nize and kill tumor cells.This lead to the idea of using MAGE g enes as the targ ets for cancer immunotherapy.This article re views the discovery,development,role,a nd therapeutic potential of MAGE tumor-associated antig ens.

关 键 词：MAGE基因 恶性肿瘤 杀伤肿瘤细胞 免疫治疗 

分 类 号：R730.5[医药卫生—肿瘤]