Studies on the Nucleophilicity and Scavenge of Superoxide Ion by Cyclic Voltammetry  

作　　者：Wei Ying\|liang, Dang Xue\|ping, Hu Sheng\|shui College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, 430072, China 

出　　处：《Wuhan University Journal of Natural Sciences》2003年第03A期866-870,共5页武汉大学学报（自然科学英文版）

基　　金：theNationalNaturalScienceFoundationofChina (60 1 71 0 2 3)

摘　　要：Superoxide ion was generated by the electrochemical reduction of oxygen at a platinum electrode in dimethylsulphoxide (DMSO). This work was focused on the nucleophilicity and scavenge of electrogenerated\|superoxide ion by cyclic voltammetry. The nucleophilic displacement reactions of superoxide ion with ethyl acetate and diethyl adipate were discussed and the reason for remarkable influence of diethyl adipate was elucidated. The scavenging activity of ascorbic acid was evaluated and the result allowed the conclusion that the scavenging ability of ascorbic acid is much lower in DMSO than in aqueous phase. UV\|spectrum of electrogenerated superoxide ion in DMSO exhibited a single absorption band with λ max at 275 nm, which certified further that the method of electrogeneration was reliable and superoxide ion was stable in DMSO.Superoxide ion was generated by the electrochemical reduction of oxygen at a platinum electrode in dimethylsulphoxide (DMSO). This work was focused on the nucleophilicity and scavenge of electrogenerated\|superoxide ion by cyclic voltammetry. The nucleophilic displacement reactions of superoxide ion with ethyl acetate and diethyl adipate were discussed and the reason for remarkable influence of diethyl adipate was elucidated. The scavenging activity of ascorbic acid was evaluated and the result allowed the conclusion that the scavenging ability of ascorbic acid is much lower in DMSO than in aqueous phase. UV\|spectrum of electrogenerated superoxide ion in DMSO exhibited a single absorption band with λ max at 275 nm, which certified further that the method of electrogeneration was reliable and superoxide ion was stable in DMSO.

关 键 词：superoxide ion DIMETHYLSULPHOXIDE cyclic voltammetry ascorbic acid 

分 类 号：R363[医药卫生—病理学]