急性白血病化疗前后血清甲状腺激素水平变化及其对疗效和预后的影响  

Changes of the thyroid hormone level in serum of acute leukemia patients before and after chemotherapy and their influence on the chemotherapeutic effect and prognosis

作　　者：夏海龙[1] 蒋玲[1] 夏瑞祥[1] 曾庆曙[1] 蔡学杰[1] 

机构地区：[1]安徽医科大学附属医院,合肥230022

出　　处：《临床中老年保健》2003年第3期169-170,共2页

摘　　要：目的　研究急性白血病化疗前后血清甲状腺激素水平变化及其对疗效和预后的影响。方法　测定患者化疗前后血清甲状腺激素水平 ,分析患者血清甲状腺激素水平的变化及其与急性白血病疗效和预后的关系。结果　化疗前患者血清甲状腺激素水平与正常对照比较无显著差异 ;化疗后患者血清甲状腺激素水平降低 ,明显低于正常对照。化疗前后患者血清甲状腺激素水平低于正常者疗效较差 ,治疗相关病死率较高 ,中位生存期较短。Objective To observe changes of the thyroid hormone level in serum of acute leukemia patients before and after chemotherapy and their influence on the chemotherapeutic effect and prognosis.Methods To measure the level of thyroid hormones in serum of aucte leukemia patients,and study their changes between before chemotherapy and after chemotherapy,investigate their impact on the chemotherapeutic effect and prognosis.Results There were no difference of thyroid hromone level between acute leukemia patients before chemotherapy and normal control group;the thyroid hormone level of patients after chemotherapy were obviously lower than those of normal control group.Chemotherapy can result in decrease of the thyroid hormone level of acute leukemia patients.The patients with lower level of thyroid hormone before and after chemotherapy had higher mortality and shorter survival period.Conclusion The lower thyroid hormones before and after chemotherapy is associated with more poor prognosis in patients with acute leukemia.

关 键 词：甲状腺激素 化疗 急性白血病 

分 类 号：R733.71[医药卫生—肿瘤]