P16蛋白在甲状腺癌组织表达与临床意义的关系  

Clinical significance on the expression of P16 protein in thyroid carcinoma

作　　者：林方才[1] 高庆云[1] 陈瑞新[2] 张德恒[2] 

机构地区：[1]北京电力医院 [2]白求恩医科大学第三临床学院

出　　处：《中国水电医学》2005年第6期324-326,共3页

摘　　要：目的探讨P16蛋白表达在甲状腺癌发生、发展中的作用及其临床意义。方法采用免疫组织化学 SP法。结果 P16蛋白在PTC、FTC组织的表达率明显高于MTC和UDC组织的表达率(P【0.05)。Ⅰ期P16 蛋白的表达率明显高于Ⅲ、Ⅳ期(P【0.05)。无淋巴结转移组P16蛋白的表达率(92.6%)高于有淋巴结转移组 (64.7%)(P【0.05)。高分化组P16蛋白的表达率(90.3%)高于低分化组(61.5%)(P【0.05)。结论 P16蛋白参与了甲状腺癌的发生及分化,与甲状腺癌的临床分期、分化程度、淋巴结转移有关,可作为临床判定预后的参考指标之一。Objective To study the relationship between expression of P16 protein and the biological behavour of thyroid carcinoma. Methods The expression of P16 protein was examined by Immunohistochemical Staining techniwue (sp method). Results The positive rates of P16 protein expression in PTC, FTC are significantly higher than that in MTC and UDC (P<0. 05). The positive rates of P16 protein expression in the Ⅰ stages of thyroid carcinoma are obviously higher than that in Ⅲ,Ⅳ stages (P< 0. 05). The level of P16 in the non - lymph node invasion group (92. 6 %) is higher than that in lymph node invasion group (64. 7 %) (P <0. 05). The positive rates of P16 (90. 3%) in the well differentiated group in PTC and FTC is higher than that in poorly diffetenriated group (61. 5 %) (P < 0. 05). Conclusions The p16 protein may take part in pathogenesis and differentiation of thyroid carcinoma. The level P16 protein expression is associated with differential degree, lymph node invasion and clinical stages of thyroid carcinoma.

关 键 词：甲状腺癌 P16蛋白 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]