大肠良恶性肿瘤AgNORs颗粒形态定量分析  

Study of AgNORs Morphometry in Benign and Malignance Colorectal Tumor

作　　者：张京伟[1] 袁宏银[1] 吴洲青[1] 

机构地区：[1]武汉大学中南医院肿瘤科,武汉430071

出　　处：《武汉大学学报（医学版）》2003年第4期332-334,共3页Medical Journal of Wuhan University

摘　　要：目的 :探讨AgNORs在大肠肿瘤中的应用价值。方法 :应用图像分析仪对 10例大肠正常粘膜、4 3例大肠腺瘤及 4 0例大肠腺癌AgNORs进行形态定量分析。结果 :①AgNORs计数、颗粒面积、颗粒面积 核面积等指标在 3组间呈递增趋势而形态系数则逐级减小 ,3组间差异有显著性。②管状腺瘤、混合型腺瘤和绒毛状腺瘤AgNORs计数及面积逐级升高且随体积增大升高明显 ,直径大于 2cm绒毛状腺瘤明显高于其它各组 ,P <0 .0 5。结论 :AgNORs形态定量指标检测是大肠肿瘤良、恶性鉴别诊断及大肠腺瘤癌前病变的检测。Objective: To explore the clinical value of AgNORs in colorectal tumor. Methods: Automatic image analysis method was used to study AgNORs morphometry in 10 cases of normal mucosa,43 cases of adenoma and 40 cases of adenocarcinoma of large bowel. Results:①In adenocarcinoma mean AgNORs praticles number, per nucleus praticles area and praticles area/nucleu area were significantly higher than those in adenoma and normal mucose. But the rate of Fcirclea was significantly lower in adenocarcinoma. ②Mean AgNORs partical number and area in mixed adenoma and villous adenoma increased gradually and was more obviously while the tumors enlarged. Especially the villous adernoma which size biger than 2 cm had a similliar pratical number and area to adenocarcionma. Conclusion: The morphometric parameters of AgNORs can be act as a useful indicators for early and distinctive diagnosis of colorectal tumor.

关 键 词：大肠肿瘤 AgNORs颗粒 形态定量分析 核仁组成区相关蛋白 

分 类 号：R735.34[医药卫生—肿瘤]