精神分裂症患者的认知状况及其P300电位研究  

The analysis on cognition and P300 potentials in schizophrenics

作　　者：秦志华[1] 孙富根[1] 穆俊林[1] 

机构地区：[1]河南省精神病医院,河南新乡453002

出　　处：《临床心身疾病杂志》2003年第3期134-135,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 探讨P300电位在评价精神分裂症患者认知功能中的作用。方法 对40例精神分裂症患者和36例健康者分别进行P300电位测定和认知能力筛查试验(CASI),并将两组结果进行比较。结果 精神分裂症患者的P300电位成分中N2、P3潜伏期延长及P3波幅降低,与健康对照组存在显著性差异(P<0.01),CASI测定中9个因子分及总分患病组均低于健康对照组,两组存在显著性差异(P<0.01或P<0.05)。结论 P300电位可作为了解精神分裂症患者的认知状况的重要指标应用于临床。Objective To investigate the effect of P300 potentials on the appraisal of cognition in schizophrenics. Methods P300 potentials test and cognitive ability screening instrument (CASI) were used for forty schizophrenics and thirty-six healthy people, the results were compared in the two groups. Results Latent periods of N2 and P3 of P300 potentials in schizophrenics were longer and the amplitude of P3 was lower than those in the controls., there was significant difference between the two groups(P < 0.01) .The nine factors scores and the total score of CASI test in schizophrenics were significantly lower than those in the controls ( P < 0.01 or P < 0.05) . Conclusion P300 potentials can be used in clinical as a momentous index to analyze cognition in schizophrenics.

关 键 词：精神分裂症 认知状况 P300电位 筛查试验 

分 类 号：R749.3[医药卫生—神经病学与精神病学]