miRNA在子宫内膜癌发病机制中的研究进展  

miRNA research progress in the pathogenesis of endometrial cancer

作　　者：唐开[1] 崔玉兰[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇产科一病区,黑龙江哈尔滨150006

出　　处：《现代肿瘤医学》2016年第5期831-833,834,共4页Journal of Modern Oncology

摘　　要：微小RNA(miRNA)是一种重要的内源性非编码RNA,在动植物及病毒中广泛存在。miRNA与肿瘤的发生、发展和预后关系密切,并参与肿瘤细胞的增殖、分化及凋亡。许多miRNA在肿瘤的形成过程中发挥着原癌基因或抑癌基因的作用。子宫内膜癌为妇科三大恶性肿瘤之一,其发病率逐年上升。现就miRNA在子宫内膜癌发病机制方面的研究进展作一简要综述。MicroRNA( miRNA) is important,noncoding single- stranded RNA that is widespread in plants and animals. miRNA is concerned with tumor development and prognosis,and plays a crucial role in tumor hyperplasia,differentiation and apoptosis. Many miRNA may play oncogenic or anti- oncogenic role in the tumor development. Endometrial cancer is one of the three major gynecological malignancies,with the increased incidence rate year by year. This article will review miRNA research progress in the pathogenesis of endometrial cancer.

关 键 词：MIRNA 妇科肿瘤 肿瘤形成 发病机制 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]