DBC1在结肠癌中的表达及其临床意义  

Expression of DBC1 and its clinical significance in human colon cancer

作　　者：张永国[1] 刘婕[2] 邓晗[1] 邵晓冬[1] 李宏宇[1] 郭晓钟[1] 

机构地区：[1]沈阳军区总医院消化内科,辽宁沈阳110016 [2]沈阳药科大学药剂实验中心,辽宁沈阳110016

出　　处：《现代肿瘤医学》2016年第11期1776-1779,共4页Journal of Modern Oncology

摘　　要：目的:研究DBC1在结肠癌中的表达及潜在的临床意义。方法:利用免疫组织化学染色的方法检测DBC1在150例结肠癌及其相应癌旁组织中的表达,分析DBC1表达与年龄、性别、部位、组织学分化程度、TNM分期、淋巴结转移、临床预后等临床参数间的相关性。结果:DBC1在结肠癌中的表达明显高于相应的癌旁组织(71.3%vs 24.7%,P<0.05)。DBC1表达水平与组织学分化程度、TNM分期、淋巴结转移密切相关(P<0.000)。DBC1表达与结肠癌的总体生存时间、结肠癌患者总体生存率密切相关,DBC1表达水平越高,患者的生存时间越短(P<0.000)。结论:DBC1在结肠癌中呈高表达,可作为结肠癌的预后判断指标,提示DBC1在结肠癌的发生发展中发挥重要作用。Objective: To study the expression of DBC1 in colon cancer and analyze its potential clinical significance. Methods: IHC was performed to detect the expression of DBC1 in 150 cases of colon cancer and the corresponding adjacent non- tumor tissues. The correlation between DBC1 expression and clinicopathologic features( age,gender,TNM stage,prognosis) were analyzed. Results: A higher positive staining of DBC1 was detected in colon cancer tissues than that in non- cancer tissues( 71. 3% vs 24. 7%,P < 0. 05). Moreover,the expression level of DBC1 was correlated with tumor histologic grade,TNM stage and metastatic status( P < 0. 000),but there was no difference between DBC1 expression and gender or age. Kaplan- Meier and Cox analysis showed that DBC1 expression was associated with shorter overall survival( P < 0. 000). Conclusion: DBC1 is overexpressed in colon cancer. DBC1 acted as a prognostic factor in colon cancer. These findings indicated DBC1 may play an important role in the colon cancer.

关 键 词：DBC1 结肠癌 预后 

分 类 号：R735.35[医药卫生—肿瘤]