机体乏氧状态对膀胱癌全膀胱切除术后患者生存状况的影响  

Effect of Hypoxia on Postoperative Living Conditions of Patients with Bladder Cancer after Radical Cystectomy

作　　者：邓助朋 

机构地区：[1]广东省台山市人民医院,529200

出　　处：《实用癌症杂志》2015年第3期374-376,共3页The Practical Journal of Cancer

摘　　要：目的探讨机体乏氧状态对膀胱癌全膀胱切除术后患者生存质量的影响。方法将78例膀胱癌全膀胱切除术患者随机分为机体常氧状态组(常氧组)57例和机体乏氧状态组(乏氧组)21例。采用免疫组化方法检测所有病例的切片标本缺氧诱导因子-1α(HIF-1α)的表达情况,将患者生存时间与多项乏氧相关因素做Kaplan-Meier分析。结果乏氧组HIF-1α表达阳性率为85.7%(18/21),常氧组HIF-1α表达阳性率为57.9%(33/57);2组中位生存时间分别为57.741个月和77.544个月,差异有统计学意义(P<0.05)。肿瘤分期高、HIF-1α高表达、机体乏氧状态、血红蛋白水平<110 g/L时患者生存时间较短(P<0.05或P<0.01)。结论机体乏氧状态可导致肿瘤内部供氧不足,促进HIF-1α表达上升,进而降低患者生存率。Objective To study the effect of hypoxia on postoperative living conditions of patients with bladder cancer after radical cystectomy. Methods 78 cases of bladder cancer patients treated with total cystectomy were randomly divided into the normoxic group 57 cases and the hypoxia group 21 cases. HIF-1α expression in biopsy specimens of all patients was detected by immunohistochemical method,the survival time and hypoxia factors were analyzed by Kaplan Meier. Results The positive rate of HIF-1α expression in the hypoxia group was 85. 7%( 18 /21),and that of the normoxic group was 57. 9%( 33 /57),the median survival time of the 2 groups were 57. 741 months and 77. 544 months. respectively,there had statistical difference( P < 0. 05);Survival time in patients with high tumor stage,higher HIF-1α expression,hypoxic condition,hemoglobin levels < 110 g / L was short( P < 0. 05 or P < 0. 01). Conclusion Hypoxia can promote HIF-1α expression,and reduce survival rate of patients.

关 键 词：缺氧 膀胱癌 HIF-1Α 血红蛋白 预后 

分 类 号：R737.14[医药卫生—肿瘤]