华蟾素联合卡培他滨治疗老年胃癌的疗效观察  

Clinical Observation of Cinobufotalin Combined with Capecitabine for Gastric Cancer in Elderly Patients

作　　者：徐冬梅[1] 刘丽娟[1] 

机构地区：[1]江西省肿瘤医院药剂科,330029

出　　处：《实用癌症杂志》2015年第3期405-407,共3页The Practical Journal of Cancer

摘　　要：目的探讨卡培他滨联合华蟾素对于老年晚期胃癌患者的临床疗效。方法选取60例老年晚期胃癌患者作为研究对象,随机分为观察组和对照组各30例,对照组采用卡培他滨治疗,观察组在此基础上联合华蟾素治疗。比较两组患者的近期疗效、不良反应、Karnofsky评分以及疼痛分级情况。结果两组患者近期疗效比较无显著性差异(P>0.05),但观察组Karnofsky评分改善和稳定患者的比例显著高于对照组,且观察组VAS评分显著低于对照组。但观察组不良反应发生率显著低于对照组。结论卡培他滨联合华蟾素治疗老年晚期胃癌近期疗效肯定,且可降低化疗期间不良反应发生率,提高患者的生活质量。Objective To analyze the clinical efficacy of cinobufotalin combined with capecitabine for advanced gastric cancer in elderly patients. Methods 60 cases of elderly patients with advanced gastric cancer were randomly divided into the observation and the control group,each with 30 patients. The control group received capecitabine therapy while the observation group received cinobufotalin combined with capecitabine. The short-term efficacy,adverse reactions,Karnofsky score and pain classification of the 2 groups were compared. Results The short-term efficacy had no significant difference( P > 0. 05) between the 2groups,but the proportion of patients with improved and stable Karnofsky scores in the observation group was significantly higher than that of the control group,and the VAS scores of the observation group were significantly lower than that of the control group.The incidence of adverse reactions in the observation group was significantly lower than that of the control group. Conclusion Capecitabine combined with cinobufotalin for advanced gastric cancer in elderly patients is effective,it can reduce the incidence of side effects during chemotherapy and improve patients’ life quality.

关 键 词：华蟾素 卡培他滨 老年 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]