紫杉醇及蒽环类药物联合化疗治疗晚期乳腺癌的临床疗效  

Clinical Efficacy of Paclitaxel and MDT Anthracycline-based Drugs for Advanced Breast Cancer

作　　者：袁鹏[1] 岳天华[1] 肖艳华[1] 朱梁军[2] 李晟[2] 陈宝安[3] 

机构地区：[1]江苏省建湖县人民医院,224700 [2]江苏省肿瘤医院,210029 [3]东南大学附属中大医院,210029

出　　处：《实用癌症杂志》2015年第3期448-450,共3页The Practical Journal of Cancer

摘　　要：目的探讨紫杉醇及蒽环类药物联合化疗治疗晚期乳腺癌的临床疗效。方法 68例老年晚期乳腺癌患者按照随机数字表法分为对照组和治疗组。对照组:采用CAF方案治疗;治疗组:采用紫杉醇联合蒽环类药物±CTX方案治疗。比较2组患者5年生存率和局部复发率、腋淋巴结复发率、生活质量、近期疗效、不良反应。结果治疗组局部复发率和腋淋巴结复发率、5年生存率分别为5.88%(2/34)、2.94%(1/34)、41.18%(14/34),与对照组14.71%(5/34)、11.76%(4/34)、29.41%(10/34)比较,P均<0.05。治疗组生活质量评分和不良反应率及近期疗效与对照组比较,P均<0.05。结论临床采用紫杉醇联合蒽环类药物±CTX方案治疗晚期乳腺癌患者,可降低局部复发率和腋淋巴结复发率,提高治疗效果。同时治疗期间所产生不良反应少,可提高患者耐受性,促进治疗顺利进行,提高患者生活质量。Objective To study the cinical efficacy of paclitaxel and MDT anthracycline-based drugs for advanced breast cancer. Methods 68 cases of elderly patients with advanced breast cancer according to random number table method were grouped into the control group and the treatment group. The control group received the CAF regimen,The treatment group received the joint anthracycline-based drugs paclitaxel and ± CTX treatment. 5-year survival rates,local recurrence rates,axillary lymph node recurrence rates,quality of life,short-term curative effects and adverse reactions of the 2 groups were compared. Results Local recurrence rate,axillary lymph node recurrence rate,and 5-year survival rate in the treatment group were 5. 88%( 2 /34),2. 94%( 1 /34),and 41. 18%( 14 /34),and those of the control group were 14. 71%( 5 /34),11. 76%( 4 /34),and 29. 41%( 10 /34)( P < 0. 05). Quality of life score,adverse reaction rate and short-term curative effects of the 2 groups had statistical difference( P < 0. 05). Conclusion Paclitaxel and ± CTX anthracycline-based drugs for advanced breast cancer can reduce local recurrence and axillary lymph nodes recurrence,improve the effect of treatment. And it has less adverse reactions during the treatment,improve tolerance,promote the smooth progress of the treatment,and improve quality of life.

关 键 词：紫杉醇 蒽环类 CTX方案 晚期乳腺癌 CAF方案 

分 类 号：R737.9[医药卫生—肿瘤]