动脉化疗栓塞与动脉灌注化疗对进展期宫颈癌的疗效观察  

Observation of Efficacy of Arterial Chemoembolization and Arterial Perfusion Chemotherapy for Advanced Cervical Cancer

作　　者：柯要军[1] 王强[1] 张杰[1] 龙晶[1] 翁翠萍[1] 

机构地区：[1]武汉科技大学附属天佑医院,441400

出　　处：《实用癌症杂志》2015年第5期685-687,共3页The Practical Journal of Cancer

摘　　要：目的比较动脉化疗栓塞与动脉灌注化疗治疗进展期宫颈癌的疗效。方法将进展期宫颈癌患者70例纳入研究对象,根据化疗方法不同分为观察组(给予动脉栓塞联合灌注化疗)和对照组(仅给予动脉灌注化疗),比较两组患者的肿瘤分期、血管新生指标、平均生存时间、远期生存情况。结果肿瘤分期:观察组患者TNM分期低于对照组;血管新生指标:观察组VEGFA、VEGFB以及VEGFC含量[(75.31±9.44)、(71.92±9.62)、(59.52±6.13)pg/ml]均低于对照组;生存情况:观察组平均生存时间[(78.65±8.26)个月]、1年、2年、3年生存率(91.43%、82.86%、74.29%)均优于对照组。结论动脉化疗栓塞是治疗进展期宫颈癌的理想方法。Objective To compare the efficacy of arterial chemoembolization and arterial perfusion chemotherapy for advanced cervical cancer. Methods 70 cases of advanced cervical cancer were enrolled and divided into the observation group( arterial chemoembolization) and the control group( arterial perfusion chemotherapy). Tumor stage,angiogenesis index,average survival time,long-term survival between the 2 group s were compared. Results Tumor stage: TNM stage in the observation group was significantly lower than that of the control group; angiogenesis index: VEGFA,VEGFB and VEGFC content in the observation group were 75. 31 ± 9. 44,71. 92 ± 9. 62,59. 52 ± 6. 13 pg / ml,which were significantly lower than those of the control group; Survival: in the observation group,average survival time was( 78. 65 ± 8. 26) months,1-year,2-year,3-year survival rates were91. 43%,82. 86%,74. 29%,which were significantly higher than those of the control group. Conclusion Arterial chemoembolization is an ideal treatment for advanced cervical cancer.

关 键 词：进展期宫颈癌 动脉栓塞 动脉灌注化疗 血管新生 

分 类 号：R737.33[医药卫生—肿瘤]