鼻腔NK/T细胞淋巴瘤的临床特征和治疗及预后影响因素  

Clinical Features and Treatment of Nasal NK/T-cell Lymphoma and Prognostic Factors

作　　者：周杰 

机构地区：[1]重庆市黔江民族医院,409000

出　　处：《实用癌症杂志》2015年第5期780-782,共3页The Practical Journal of Cancer

摘　　要：目的研究鼻腔NK/T细胞淋巴瘤患者的临床特征、治疗及影响预后的相关因素。方法选取98例住院接受治疗的鼻型NK/T细胞淋巴瘤患者为研究对象,分析疾病的临床特征和治疗方法,并将影响患者预后的可能因素进行单因素及多因素分析。结果完全缓解、部分缓解、稳定、进展例数分别为61例、29例、3例、5例。单纯化疗完全缓解率为17.39%,单纯放疗为62.50%,化疗联合放疗为82.35%;放化疗联合治疗与单纯放疗、单纯化疗间的完全缓解率存在显著性差异(P<0.05),但单纯放疗与单纯化疗间的完全缓解率无明显差异(P>0.05)。单因素分析表明,患者年龄、PS评分、疾病分期、ALB、淋巴细胞计数、IPI、LDH、近期疗效及治疗模式与患者预后相关。多因素分析表明,患者年龄、近期治疗的临床疗效及疾病分期是鼻腔NK/T细胞淋巴瘤患者预后的独立相关因素。结论鼻腔NK/T细胞淋巴瘤主要病变部位为韦氏环和鼻腔,常见全身症状,男性发病率明显高于女性,其主要治疗手段为放疗和化疗,患者年龄、近期疗效、疾病分期是影响其预后的独立危险因素。Objective To study the clinical features,treatment and prognosis of nasal NK/T cell lymphoma. Methods98 patients with nasal type NK / T cell lymphoma were selected. Clinical features and treatment were analyzed. The possible factors affecting the prognosis of patients were analyzed by single and multiple factors analysis. Results Complete remission,partial remission,steady disease,and progressive disease were 61 cases,29 cases,3 cases,and 5 cases,respectively. Complete remission rate of chemotherapy was 17. 39%,complete remission rate of radiotherapy alone was 62. 50%,complete remission rate of chemoradiotherapy was 82. 35%; There had significant difference in complete remission rate between the combination treatment and single treatment( P < 0. 05),but radiotherapy and chemotherapy had no significant difference in complete remission rate( P >0. 05). Single factor analysis showed that age,PS score,stage of disease,ALB,lymphocyte count,IPI,LDH,short-term effects and treatment patterns were associated with the prognosis of the patients. Multivariate analysis showed that clinical efficacy,age,disease,therapeutic staging were independent prognostic factors of patients with nasal NK / T cell lymphoma. Conclusion Main lesions of nasal NK / T cell lymphoma are in Waldeyer’s ring and the nasal cavity,there have common systemic symptoms,the incidence of male is higher than that of female,the main treatment methods are radiotherapy and chemotherapy,age,short-term efficacy,disease stage are independent prognostic risk factors.

关 键 词：鼻型NK/T淋巴细胞瘤 非霍奇金淋巴瘤 多因素分析 单因素分析 预后 

分 类 号：R739.62[医药卫生—肿瘤]