抗乙型肝炎病毒基因治疗的若干进展  

Recent advances in genetic therapy for anti-hepatitis B virus

作　　者：余永胜[1] 陈有华[2] 

机构地区：[1]上海市第六人民医院传染科,上海200233 [2]皖南医学院弋矶山医院传染科,芜湖241001

出　　处：《中国临床药理学与治疗学》2002年第6期574-576,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：随着分子生物学特别是基因工程技术的发展 ,抗乙型肝炎病毒基因治疗有较深入的研究 ,利用基因重组、转基因及反义核酸等技术 ,在细胞水平或通过动物实验阶段的研究 ,基因有关治疗在抗乙肝病毒、抑制乙肝病毒复制中的作用已被证实。本文对转基因干扰素、DNA疫苗 (DNA免疫 )、反义寡核苷酸、三螺旋形成寡核苷酸 (反基因寡核苷酸 )。With the development of molecular biology, especially gene engineering technique, genetic therapy for anti hepatitis B virus was deeply researched. Employing techniques of gene recombinant, transgene, and anti sense nucleic acid etc, the function of genetic therapy for anti hepatitis B virus was verified in cellular level or through animal experiment. In this article, studies on gene trangenically IFN, DNA vaccine (DNA immunization), antisense oligodeoxynucleotide (ONas), triple helix forming oligodeoxynucleotide (TFO), anti gene oligodeoxynucleotide (ONan), ribozyme were reviewed.

关 键 词：乙型肝炎转基因干扰素 DNA疫苗 反义寡核苷酸 三螺旋形成寡核苷酸 核酶 

分 类 号：R512.62[医药卫生—内科学]