清开灵对内毒素性发热家兔的解热机制研究  

Study on the Mechanism of the Antipyretic Effects of Qingkailing Injection on the Rabbits with Endotoxin-Induced Fever

作　　者：蒋玉凤[1] 张丹卉[1] 黄启福[1] 李克玲[1] 王谦[1] 贾旭[1] 严京[1] 

机构地区：[1]北京中医药大学病理教研室,北京100029

出　　处：《北京中医药大学学报》2003年第5期53-55,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：北京中医药大学科研课题

摘　　要：目的　探讨清开灵注射液 (简称清开灵 )对内毒素性家兔发热的解热机制。方法　复制内毒素性家兔发热模型 ,以数字温度计测量结肠的温度 ,用放免法测定下丘脑中的IL 1β和cAMP、脑脊液中的cAMP、腹中隔区 (VSA)的精氨酸加压素 (AVP)的含量。结果　①清开灵对内毒素性发热家兔有显著性的解热效应 (P <0 0 1) ;②明显抑制下丘脑IL 1β及cAMP的生成 (P <0 0 1) ;③显著降低脑脊液 (CSF)中cAMP及腹中隔区AVP的含量 (P <0 0 1)。结论　清开灵对内毒素性发热的重要解热机制可能与抑制内生致热原和中枢发热介质的生成 。Objective To investigate the mechanism of the antipyretic effects of Qingkailing Injection (QI) on the rabbits with endotoxin induced fever. Methods The rabbit model of endotoxin induced fever was established for the experiment. The digital thermograph was used to measure the colonic temperature. Radioimmunoassay was used to measure the levels of IL 1β and cAMP in the hypothalamus, cAMP in cerebrospinal fluid and AVP in the ventral septal area. Results QI exerted a marked antipyretic effect on the rabbits with endotoxin induced fever ( P <0 01), remarkably inhibit the production of IL 1β and cAMP in the hypothalamus ( P <0 01), and markedly reduce the levels of cAMP in cerebrospinal fluid and AVP in the ventral septal area ( P <0 01). Conclusion The mechanism of the antipyretic effects of QI against endotoxin induced fever may be related with the inhibition of the production of endogenous pyretogens and central febrile media and the promotion of the release of antipyretic substances.

关 键 词：内毒素 发热 白细胞介素-Β 腺苷环-磷酸 精氨酸加压素 清开灵注射液 家兔 

分 类 号：R364.6[医药卫生—病理学]