成釉细胞瘤及牙源性角化囊肿中ICAM-1和VCAM-1的表达  

Expression of ICAM-1 and VCAM-1 in Human Ameloblastoma and Odontogenic Keratocyst

作　　者：王洁[1] 钟鸣[1] 张陆荘[1] 王岩[1] 王兆元[1] 

机构地区：[1]中国医科大学口腔医学院病理科,辽宁沈阳110002

出　　处：《上海口腔医学》2003年第4期273-276,共4页Shanghai Journal of Stomatology

基　　金：辽宁省科委基金资助项目(9922500-25)

摘　　要：目的探讨细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)在成釉细胞瘤(AB)及牙源性角化囊肿(OKC)中的表达及其与AB、OKC病理学特征的关系。方法对38例AB、10例OKC、7例正常口腔黏膜(NOM)组织进行免疫组织化学SP法检测,结合病例病理特征进行分析。结果ICAM-1和VCAM-1在AB、OKC和NOM3组表达组间比较,具有显著统计学差异(P<0.05)。ICAM-1在AB中的阳性率达65.2%,显著高于NOM(14.3%),OKC(60.0%)与NOM未见显著统计学差异。VCAM-1在AB中的阳性血管数也显著高于OKC和NOM。ICAM-1和VCAM-1表达与AB的组织病理分型、年龄、性别和发生部位无明显相关性(P>0.05)。结论细胞黏附分子ICAM-1和VCAM-1与AB及OKC的发生、发展及细胞分化与增殖有关。Objective To study the e xpression of ICAM-1and VCAM-1in human ameloblastoma(AB)and odontogenic keratocys t(OKC)and investigate the relation of ICAM-1and VCAM-1with the pathologic charac teristic of AB and OKC.Methods The specimens of38cases of AB,10cases of OKC,7cas es of normal oral mucosa(NOM)were examined by streptovidin-biotin method.Their e xpression was analyzed combining the pathologic characteristics.Results Comparin g AB with OKC and NOM,there was a significant difference in ICAM-1and VCAM-1(P<0 .05).The positive expression of ICAM-1in AB was65.2%,much higher than that in NO M(14.3%).There was no difference between the expression of ICAM-1in OKC(60.0%)an d in NOM.The positive vessels number stained by VCAM-1in AB was significantly hi gher than that in OKC and NOM.The expression of ICAM-1and VCAM-1had no correlati on to age,sex,histological types,lesion locations(P>0.05).Conclusions ICAM-1and VCAM-1play an important role in genesis,development of AB and OKC and are relate d to cell differentiation and proliferation.

关 键 词：牙源性成釉细胞瘤 牙源性角化囊肿 ICAM-1 VCAM-1 免疫组化 

分 类 号：R739.8[医药卫生—肿瘤]