高龄肺癌病人血清sIL-2R、sIL-6R和TNF-α水平测定及临床意义  

EXPRESSION AND CLINICAL IMPLICATIONS OF SERUM sIL-2R, sIL-6R AND TNF-α LEVELS IN AGED PATIENTS WITH LUNG CANCER

作　　者：匡弢[1] 王秀美[1] 吕静[1] 

机构地区：[1]青岛大学医学院附属医院特需病房,山东青岛266003

出　　处：《齐鲁医学杂志》2003年第3期256-257,共2页Medical Journal of Qilu

摘　　要：①目的　探讨高龄肺癌病人血清细胞因子可溶性白细胞介素 2受体 (sIL 2R)、可溶性白细胞介素 6受体 (sIL 6R)和肿瘤坏死因子α(TNF α)水平及其临床意义。②方法　采用双抗体夹心ELISA法 ,测定 5 4例老年肺癌病人和 4 0例健康人 (对照组 )血清sIL 2R、sIL 6R和TNF α水平。③结果　老年肺癌病人sIL 2R、sIL 6R和TNF α水平均高于对照组 (t=14 .6 9～ 6 9.85 ,P <0 .0 1) ,肺癌未手术伴淋巴结转移病人sIL 2R、sIL 6R和TNF α水平均高于术后复发者 (t =3.2 3～ 37.2 1,P <0 .0 5 )。④结论　血清中sIL 2R、sIL 6R和TNF α水平可能与肺癌发生、发展有关。Objective To investigate the clinical significance of serum interleukin 2 receptor (sIL-2R), interleukin 6 receptor (sIL-6R)and tumor necrosis factor α (TNF-α) levels in aged patients with lung cancer. Methods ELISA techniques was applied to determine the levels of sIL-2R, sIL-6R, and TNF-α in 54 aged patients with lung cancer and 40 healthy subjects. Results The sIL-2R,sIL-6R and TNF-α levels were significantly higher in the aged patients with lung cancer than in the controls ( t=14.69-69.85,P<0.01). The levels of sIL-2R, sIL-6R and TNF-α in the patients who had lymph node metastasis and had not been operated were higher than those in the patients who relapsed after the operation (t=3.23-37.21,P<0.01). Conclusion The activities of sIL-2R, sIL-6R and TNF-α in the serum may be associated with the development of the lung cancer. The determination of serum sIL-2R,sIL-6R and TNF-α levels can help to observe the state of the lung cancer.

关 键 词：肺癌 SIL-2R SIL-6R TNF-Α 测定 老年人 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]