胃癌组织p53、p16基因表达的研究  

Immunohistochemical analysis of p53 and p16 genes expression in human stomach cancer

作　　者：张国强[1] 王宽[1] 张玉宝[1] 赵家宏[1] 

机构地区：[1]哈尔滨医科大学第三临床医学院,哈尔滨150040

出　　处：《实用肿瘤学杂志》2003年第3期174-176,共3页Practical Oncology Journal

摘　　要：目的 探讨胃癌p53、p16基因表达与临床病理因素的关系。方法 采用免疫组化SP法检测63例胃癌患者的原发灶、转移淋巴结及正常粘膜组织的p53、p16基因表达情况,分析其与临床病理因素之间的关系。结果 p53基因与胃癌淋巴转移密切相关,p16基因表达与胃癌临床病理诸因素无关,p53高表达与p16低表达联合与淋巴结转移有关。结论 p53基因的阳性表达与胃癌恶性程度,特别是与淋巴结转移有关,可以作为胃癌淋巴结转移的标志物。Objective To investigate the relationship between p53 and p16 genes with clinical pathological factors of patients with stomach cancer. Methods Expression of p53 and p16 genes in specimens of primary tumor, metastasis lymph nodes and normal membrane of 63 patients with gastric cancer were immunohistochemically stained, and the relationship between the gene expression and clinical pathological factors was analyzed. Results The overexpression of p53 gene was correlated with the lymph nodes metastasis and was not relative with other clinic pathological factors. The lowexpression of p16 gene was not relative with all the factors. Conclusion The p53 genes overexpression would be a good marker for human gastric cancer, it is relative with lymph node metastasis.

关 键 词：胃癌 P53 P16 基因表达 病理 免疫组化SP法 淋巴结转移瘤 

分 类 号：R735.2[医药卫生—肿瘤] R730.231.3[医药卫生—临床医学]