川芎嗪、三七皂甙治疗不同类型急性脑梗死的疗效差异  

The different effectiveness of Ligustrazine and notoginsheng saponin in the treatment of various types of acute cerebral infarction

作　　者：张久亮[1] 孙丽凤 王锋 史载祥[1] 毛建生[1] 杜金行[1] 曹启富[1] 

机构地区：[1]中日友好医院中医心肾科,北京100029 [2]山东省烟台中医医院内科,山东烟台264000 [3]甘肃省通渭县人民医院中医内科,甘肃通渭743300

出　　处：《中日友好医院学报》2003年第4期210-212,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的 :观察常用中药静脉注射液川芎嗪、三七皂甙对不同类型急性脑梗死治疗效果的差异。方法 :选择发病 3d以内急性脑梗死患者 12 4例 ,分为川芎嗪治疗组 6 9例 ,三七皂甙治疗组 5 5例 ,疗程 15d。观察其神经缺损分数的变化 ,比较两组的总疗效及在不同证型、不同部位的疗效差异。结果 :川芎嗪、三七皂甙的总有效率分别为 73.9%、6 3.6 %。风痰瘀血、痹阻脉络型中 ,川芎嗪治疗组的有效率 (84 .6 % )显著高于三七皂甙组(5 0 % ) (P <0 .0 5 ) ;肝肾阴虚、风阳上扰型中 ,三七皂甙组的有效率 (93.3% )显著高于川芎嗪组 (5 3.5 % ) (P <0 .0 5 )。结论 :川芎嗪适用于风痰瘀血、痹阻脉络型 ,三七皂甙适用于肝肾阴虚、风阳上扰型。Objective:To investigate the differences between Ligustrazine and notoginsheng saponin in the treatment of acute cerebral infarction. Methods: 124 patients with acute cerebral infarction within 3 days were selected, and were divided into Ligustrazine group (69 patients) and notoginsheng saponin group (55 patients). Results: The therapeutic effectiveness of the 2 groups were 73.9% and 63.6%, respectively. In the type of wind-phlegm and blood stasis, therapeutic effectiveness of the 2 groups were 84.6% and 50%, respectively. The difference in effectiveness between Ligustrazine group and notoginsheng saponin group was significant ( P <0.05). In the type of wind-yang up-boring and kidney-liver yin deficiency, therapeutic effectiveness of the 2 groups were 53.5% and 93.3%, respectively. The therapeutic effectiveness of notoginsheng saponin was much better than that of Ligustrazine ( P <0.05). Conclusion: Ligustrazine is suitable to the type of wind-phlegm and blood stasis. notoginsheng saponin is suitable to the type of wind-yang up-boring and kidney-liver yin deficiency.

关 键 词：川芎嗪 三七皂甙 药物治疗 急性脑梗死 疗效 静脉注射 辩证施治 

分 类 号：R743.3[医药卫生—神经病学与精神病学]