直肠癌旁移行黏膜的生物学特征对患者预后评估的意义(英文)  

Significance of the biological characteristics of transitional mucosa adjacent to rectal cancer for patient prognosis

作　　者：苏琪[1] 殷红专[1] 花亚伟[2] 宋桂花[3] 韩霞[1] 张宏[1] 冯勇[1] 陈春生[1] 乔雷[1] 刘恩卿[1] 吴硕东[1] 

机构地区：[1]中国医科大学附属第二医院普外四科,辽宁省沈阳市110003 [2]河南省肿瘤医院普外科,河南省郑州市450003 [3]沈阳市于洪区红十字会医院内科,辽宁省沈阳市110032

出　　处：《中国临床康复》2003年第23期3208-3209,共2页Chinese Journal of Clinical Rehabilitation

基　　金：辽宁省自然科学基金(972255)~~

摘　　要：目的:探讨直肠癌旁移行黏膜(TM)病理学性质及其对患者预后的影响。方法:2000-01/2001-01应用免疫组化及粘液组化方法观察了81例直肠癌及癌旁黏膜的增殖细胞核抗原(PCNA)表达情况及癌旁TM的变化规律。结果:在癌旁TM、非典型增生及癌组织PCNA呈递增表达,与正常粘膜相比,差异非常显著(F=8.92,P<0.01),癌旁TM范围在粘液癌明显大于乳头状癌及管状腺癌(t=3.15-3.41,P<0.01),在DukesC期明显大于DukesA、B期(t=2.51-3.10,P<0.05,P<0.01)。结论:直肠癌旁TM具有一定的恶性潜势,直肠癌旁TM的范围与直肠癌的类型及进展密切相关,有利于对患者预后的评估。AIM:To study the pathological characteristics of the transitional mucosa (TM) adjacent to rectal carcinoma and their significance in prognostic assessment of the patients. METHODS: Immunohistochemical and mucin histochemical methods were employed to observe the expression of PCNA and the changes in the TM adjacent to the carcinoma in 81 cases of rectal carcinoma. RESULTS: PCNA expression was the highest in the cancer foci and gradually decreased in atypical dysplasia, TM and normal mucosa (F=8.92, P< 0.01). The distribution of TM adjacent to the mucinous adenocarcinoma was more extensive than that to the papilla adenocarcinoma and tubular adenocarcinoma (t=3.15- 3.41, P< 0.01), and the TM adjacent to the rectal carcinoma in Dukes C stage was more extensive than that in stages A and B (t=2.51- 3.10, P< 0.01, P< 0.05).

关 键 词：直肠癌旁移行黏膜 生物学特征 预后 评估 免疫组化 粘液组化方法 

分 类 号：R735.37[医药卫生—肿瘤]