营养型口服补铁剂的研制及其生物利用度研究  

PREPARATION OF A NEW NUTRITIONAL IRON SUPPLEMENT AND STUDY ON ITS BIOAVAILABILITY

作　　者：孟凡德[1] 刘学启 李明霞[1] 赵全芹[1] 

机构地区：[1]山东大学化学与化工学院,济南250012 [2]济南市药检所,济南250001

出　　处：《营养学报》2003年第3期245-247,共3页Acta Nutrimenta Sinica

基　　金：山东省卫生厅基金 (No.975 3)

摘　　要：目的 :　从黑木耳中提取黑木耳多糖 ,尔后与铁 ( )合成一种新的营养型补铁剂。方法 :　以黑木耳多糖与铁 ( )作用合成黑木耳多糖铁 ( )配合物 (APC) ,并且测定了 APC的理化性质和生物利用度。结果 :　APC的水溶液中不存在游离铁 ( ) ,表明铁 ( )与黑木耳多糖形成了稳定的配合物。在 p H值 3～ 1 1范围内不水解 ,无沉淀产生 ;在 3 7℃和模拟体液中 ,测定 APC的动力学实验 ,可见 APC能被食物中的还原剂还原 ,尔后被体内吸收。溶出性能研究表明 ,APC的铁 ( ) 6 h基本溶出。效用研究表明 ,APC在人体内维持较高浓度时间长 ,有利于机体吸收。结论 :　 APC无刺激气味 ,自由离子对胃肠道无强烈的刺激作用 ,有望成为理想的补铁剂。Objective: Auricularid auricula polysaccharide was isolated from Auricularia auricula, and then iron(Ⅲ)-Auricularia auricula polysaccharide complex(APC) was prepared. Methods: APC was synthesized with FeCl 3 and its physico-chemical property and bioavailability were determined. Results: APC was able to dissolve in water and its solution assumed neutral, and this complex did not precipitate at pH from 3 to 11 in water solution, so APC was very stable. Fe(Ⅲ) in APC could be reduced to Fe(Ⅱ) by ascorbic acid. Extracorporeal dissolubility showed Fe(Ⅲ) in APC could be exhibited in 6 h. Bioavailabity studies showed the iron from APC could be well absorbed and maintained longer in serum concentration. Conclusion: APC was able to have better bioavilability as an iron supplement.

关 键 词：营养型口服补铁剂 生物利用度 黑木耳多糖 铁(Ⅲ) 理化性质 

分 类 号：R943[医药卫生—药剂学] R969.1[医药卫生—药学]