老年黄斑变性早期中央25°暗视敏感度研究  

Scotopic sensitivity of central 25° in early age-related macular degeneration

作　　者：陈长征[1] 吴乐正[1] 江福钿[1] 梁炯基[1] 吴德正[1] 

机构地区：[1]中山大学中山眼科中心,510060

出　　处：《中国实用眼科杂志》2003年第9期646-648,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的 :研究老年黄斑变性早期患者眼底后极部暗视敏感度的变化。方法 :在 2 5例老年黄斑变性早期患者和 16例正常老年人分别检测中央 2 5°81个位点暗视敏感度和明视敏感度 ,比较两组暗视和明视敏感度。暗视敏感度检测是暗适应后用蓝光刺激 (W 47b 45 0nm )、 0背景光 ;明视敏感度用白光刺激、背景光 3 1 4asb。结果 :老年黄斑变性组暗视和明视敏感度比正常老年对照组降低 ,但暗视敏感度降低更明显 ,暗视敏感度降低随离心度增加而减少 ,在距中心凹 2 5°～ 5°下降最明显。结论 :老年黄斑变性早期视杆细胞功能下降 ,中心凹旁下降最明显 ,进一步验证视杆细胞易感性学说。老年黄斑变性暗视敏感度检测 ,可作为早期诊断和病程监测一个有用的检查手段。Objective:To test scotopic sensitivity and investigate whether there is rod system dysfunction in the central retina in early stage of age-related macular degeneration (AMD). Methods:Scotopic (450nm) and photopic (white) sensitivity were measured at 81 loci in central 25° of retina in 25 patients with early stage AMD,and the results were compared with older adult normal controls. Results:Mean scotopic sensitivity of AMD patients was significantly lower than that of normal subjects.The ratio of reduced scotopic sensitivity was higher than that of photopic sensitivity in patients with the losses of scotopic and photopic sensitivities.The loss of scotopic sensitivity decreased with the increasing of eccentricity,and the greatest deficit was from 2 5° to 5 0°. Conclusions:Scotopic sensitivity decreased and parafoveal rod cells had a selective vulnerability in early stage of AMD patients.Scotopic sensitivity testing in macula may be a useful tool to measure the fundus pathology and to diagnose the AMD.

关 键 词：黄斑变性 老年人 暗视敏感度 视野检查法 诊断 视杆细胞 

分 类 号：R774.5[医药卫生—眼科]