肝介入结合中药治疗大肠癌肝转移临床疗效观察  

Clinical evaluation of integration of transcatheter arterial chemoembolization a nd traditional Chinese medicine in treating metastatic liver cancer

作　　者：孟志强[1] 徐益语[1] 刘鲁明[1] 宋明志[1] 黄雯霞[1] 

机构地区：[1]复旦大学附属肿瘤医院中医科,上海200032

出　　处：《中西医结合学报》2003年第3期187-188,233,共3页Journal of Chinese Integrative Medicine

摘　　要：目的　评价肝介入结合中药治疗大肠癌肝转移的临床疗效、毒副反应及患者生活质量的改善情况。方法　 3 9例无其它部位转移的大肠癌肝转移病人 ,随机分为治疗组 (肝介入结合中药 )和对照组 (单纯肝介入 ) ,对照组使用氟尿苷、吡柔比星、顺铂介入治疗 ,治疗组除介入外再结合健脾理气为主的中药。治疗后评价生存率、生活质量变化、副反应以及出现其它部位转移的情况。结果　治疗组的有效率为 3 0 % ,如果包括微效 (MR)病人有效率可达 45% ,中位生存时间为 18.6个月 ,1、2、3年生存率分别为 70 .2 %、40 .3 %、13 .0 %。而对照组有效率为 15.8% ,包括MR的有效率为 3 6.8% ,中位生存时间为 14 .3个月 ,1、2、3年生存率分别为 68.7%、2 9.5%、10 .3 %。生活质量评价量表提示治疗组的生活质量改善情况优于对照组 ,并且治疗组较少出现其它部位的转移 ,耐受性良好。结论　肝介入结合健脾理气为主的中药治疗大肠癌肝转移可以获得较好的疗效和生活质量 。ObjectiveTo evaluate the treatment effect, quality o f life and side-effect of transcatheter arterial chemoembolization (TACE) and t raditional Chinese medicine (TCM) in treating metastatic liver cancer. Met hodsThirty-nine cases of colon metastatic liver cancer were randomly di vided into two groups. Both TACE and TCM were used in the treatment group, while only TACE was used in the control group. The drug used in TACE included floxuri dine, pirarubicin, cisplatin, and the herbs for strengthening the spleen and reg ulating Qi were used in TCM. ResultsThe response rate in the treat ment group was 30% (45% including minor remission patients), and the median surv ival time was 18.6 months. While in the control group the response rate was 15.8 % (36.8% including minor remission patients), and the median survival time was 1 4.3 months. The 1-, 2-, 3- year survival rates of treatment group and the con trol group were 70.2%、40.3%、13.0% and 68.7%、29.5%、 10.3% respectively. Th ere were fewer other organ metastases in the treatment group. The score from the EORTC quality of life questionnaire QLQ-C30 in treatment group was ligher than that in the control group. ConclusionIntegration of TACE and TCM in treating colon metastatic liver cancer has better results.

关 键 词：肝介入 中药治疗 大肠癌 肝转移 疗效观察 

分 类 号：R735.3[医药卫生—肿瘤]