银杏外种皮多糖胶囊制剂治疗中晚期上消化道恶性肿瘤的临床研究  

Clinical study on treatment of patients with upper digestive tract malignant tum ors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation

作　　者：陈华圣[1] 翟范[2] 褚云飞[3] 徐芳[4] 许爱华[5] 贾玲昌[6] 

机构地区：[1]扬州大学医学院方药教研室,江苏扬州225001 [2]江苏省苏北人民医院中医肿瘤内科,江苏扬州225001 [3]扬州市第一人民医院消化内科,江苏扬州225002 [4]江苏省苏北人民医院肿瘤放化疗科,江苏扬州225001 [5]扬州大学医学院药理学教研室,江苏扬州225001 [6]江苏省苏北人民医院药剂科,江苏扬州225001

出　　处：《中西医结合学报》2003年第3期189-191,共3页Journal of Chinese Integrative Medicine

基　　金：江苏省科技厅社会发展基金资助项目 (BS2 0 0 0 0 86 )

摘　　要：目的　观察银杏外种皮多糖胶囊制剂治疗中晚期上消化道恶性肿瘤的临床疗效。方法　 86例中晚期上消化道恶性肿瘤患者口服银杏外种皮多糖胶囊制剂 ,观察比较用药前后患者的临床症状和生存质量的改善情况。其中对于单用该制剂治疗的 3 2例胃癌患者 ,用电子胃镜观察用药前后肿瘤大小的变化 ,计算肿瘤的客观缓解率 ,并进行生存期的随访。对于结合放疗的患者观察其血象的变化。结果　该制剂能明显改善患者的临床症状 ,显著提高患者的卡氏评分。在单用该制剂治疗的3 2例胃癌患者中 ,完全缓解 2例 (6.3 % )、部分缓解 2 2例 (68.8% )、稳定 5例 (15.6% ) ,且生存期显著延长。该制剂还能改善放疗引起的患者造血功能的抑制和体重的下降。ObjectiveTo observe the clinical efficacy of Gin kg o biloba exocarp polysaccharides (GBEP) capsule preparation in treating upper digestive tract malignant tumors of middle and late stage. Methods Eighty-six patients of the upper digestive tract malignant tumors were treate d with GBEP capsule preparation taken orally. The clinical symptoms and the qual ities of life of the patients with single GBEP and combined with operation, radi otherapy or intervention chemotherapy were observed. The tumor size was measured by electronic gastroscope before and after treatment with single GBEP. Objectiv e response rate (RR) of the tumor was calculated. The survival period of patient was observed. The changes of blood routine examination in the patients treated with radiotherapy were observed. ResultsGBEP preparation could ma rkedly improve the patients’clinical symptoms. Karnofsky scoring of the patient s markedly increased after treatment. There were 2 CR(complete response, 6.3%) , 22 PR(partial response, 68.8%)and 5 SD(stable disease, 15.6%) of 32 cases with single GBEP preparation. The survival periods of the 32 cases were markedly prolonged. The preparation could relieve the inhibited hematopietic function an d the weight loss due to radiotherapy. ConclusionGBEP capsule prep aration has some definite therapeutic effects on upper digestive tract malignant tumors of middle and late stage.

关 键 词：银杏外种皮多糖胶囊制剂 中晚期 上消化道恶性肿瘤 临床研究 中医药疗法 

分 类 号：R735[医药卫生—肿瘤]