癌胚抗原免疫细胞化学检查提高脑膜癌病的诊断敏感性  

Carcinoembryonic antigen immunocytochemistry examination increase diagnosis sensitivity of meningeal carcinomatosis

作　　者：庄建华[1] 李焰生[1] 倪麟[2] 赵忠新[1] 赵瑛[1] 黄坚[1] 

机构地区：[1]第二军医大学长征医院神经内科,上海200003 [2]上海第二医科大学瑞金医院血液科,上海200025

出　　处：《第二军医大学学报》2003年第9期1019-1021,共3页Academic Journal of Second Military Medical University

摘　　要：目的 :探讨癌胚抗原 (CEA)免疫细胞化学方法在诊断脑膜癌病 (meningealcarcinomatosis,MC)中的作用。 方法 :对1 3例确诊为MC患者的 2 1份脑脊液标本、5例非MC患者的 7份标本分别进行常规脑脊液细胞学检查和CEA免疫细胞化学检查。 结果 :常规脑脊液细胞学检查阳性率 4 2 .86 % (9/ 2 1 ) ,CEA免疫细胞化学检查阳性率 80 .95 % (1 7/ 2 1 ) ,两者相差显著(P <0 .0 5 ) ;其中对首次腰穿获得的脑脊液标本检查 ,两种方法的阳性率分别为 30 .77% (4 / 1 3)和 76 .92 % (1 0 / 1 3) ,两者相差也显著 (P <0 .0 5 ) ;非脑膜癌病患者的脑脊液检查结果均为阴性。 结论 :在诊断脑膜癌病时 ,CEA免疫细胞化学检查的敏感性高于常规脑脊液细胞学检查 。Objective:To assess the role of carcinoembryonic antigen (CEA) immunocytochemistry in the diagnosis of meningeal carcinomatosis. Methods:Twenty one cerebrospinal fluid specimens from 13 patients with meningeal carcinomatosis and 7 specimens from 5 non meningeal carcinomatosis patients were tested with routine cytologic examination and CEA immunocytochemistry examination. Results:The positive rate of routine cerebrospinal fluid cytologic examination and CEA immunocytochemistry examination were 42.86%(9/21) and 80.95%(17/21),respectively;there was significant difference ( P < 0.05), and the 2 positive rates were 30.77%(4/13) and 76.92%(10/13) in the first cerebrospinal fluid specimens; there was also significant difference( P <0.05).The results of cerebrospinal fluid specimens examination from non meningeal carcinomatosis patients were all negative. Conclusion:The sensitivity of CEA immunocytochemistry examination is superior to that of routine cerebrospinal fluid cytologic examination in the diagnosis of meningeal carcinomatosis, and the specificity of the former is also higher.

关 键 词：脑膜癌病 癌胚抗原 免疫细胞化学 诊断 脊液细胞学检查 

分 类 号：R739.45[医药卫生—肿瘤]