非小细胞肺癌中p65和C-myc的表达及意义  

Expression and implication of p65 and C-myc proteins in non-small cell lung carcinoma

作　　者：李奇志[1] 张胜名[2] 毛永荣[1] 吴建平[1] 吴昌明[1] 罗萍[1] 刘铭球[2] 李蓓云[2] 

机构地区：[1]湖北省肿瘤医院头颈外科,武汉430079 [2]武汉大学医学院病理教研室

出　　处：《肿瘤防治研究》2003年第5期359-360,363,共3页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金资助项目 (39870 30 5 )

摘　　要：目的　探讨 p6 5和C myc蛋白在非小细胞肺癌 (NSCLC)组织中的表达及临床意义。 方法　在肺支气管粘膜上皮不典型增生 11例、NSCLC 4 0例中 ,用免疫组化二步法检测 p6 5和C myc蛋白的表达 ,并将结果进行相关分析。结果　p6 5和C myc蛋白在肺癌组织中的表达与在肺支气管粘膜上皮不典型增生的表达比较差异均有显著性 (P <0 .0 1) ;p6 5和C myc蛋白在肺癌的表达与肺癌组织类型、分化及转移无关 (P >0 .0 5 ) ;肺癌中 p6 5与C myc的表达具有相关性 (Pearson列联系数 =0 .4 14 3,P <0 .0 1)。结论　p6 5和C myc蛋白在NSCLC组织中表达上调 ,提示可能通过抑制肺癌细胞凋亡 ,对肺癌的发生发展起重要促进作用。Objective To study the expression of protein p65 and C-myc in non-small cell lung carcinoma(NSCLC) and their mutual correlations and implication. Methods In 11 normal bronchial epithelium and 40 NSCLC, two steps immunohistochemistray was used in the monitor of p65 and C-myc proteins, and the relationship between results and clinical pathological characteristics were analyzed.Results The positive expression rates of p65 and C-myc proteins of lung cancer tissues were quite significant difference of it expression in normal bronchial epithelium dyspeasia ( P < 0.01 ); The expression of p65 and C-myc proteins were not correlated with types and differentiation degree of lung cancer tissues, as well as it was not correlated with transferred lymph node. In lung cancer, p65 was correlated with C-myc positively (Pearson列联系数= 0.4143 , P < 0.01 ). Conclusion Upregulation of p65 and C-myc proteins expression in NSCLC manifest that it can promote lung carcinogenesis by suppressing lung cancer cell apoptosis.

关 键 词：非小细胞肺癌 P65蛋白 C-MYC蛋白 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]