CD44v6、EGFR及nm23-H1基因蛋白在食管鳞癌组织中的表达及意义  

The protein expressions and significances of CD44V6、EGFR and nm23-H1 genes in esophageal squamous cell carcinoma

作　　者：陈海霞[1] 武培敬[1] 许艳梅[1] 韩庶勇[1] 武卫华[1] 

机构地区：[1]山东省单县中心医院,274300

出　　处：《肿瘤防治研究》2003年第5期388-390,共3页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨食管鳞癌中CD4 4v6、EGFR及nm2 3 H1蛋白表达的意义。方法　应用免疫组化S P法检测 5 0例食管鳞癌中CD4 4v6、EGFR及nm2 3 H1蛋白表达。结果　CD4 4v6、EGFR、nm2 3 H1蛋白表达总阳性率分别 6 4 %、70 %、5 0 % ;显示CD4 4v6及EGFR阳性表达率与食管鳞癌分化程度、浸润深度及淋巴结转移率呈正相关 (P <0 .0 5及P <0 .0 1) ,与患者预后呈负相关 (P <0 .0 0 5 ) ;而nm2 3 H1蛋白表达则与以上两者表达状况相反。结论　同时检测食管鳞癌中CD4 4v6、EGFR及nm2 3 H1基因蛋白表达水平 ,对判断食管鳞癌恶性程度、浸润转移潜能及评估患者预后有一定参考价值。Objective To explore the protein expressions and their significances of CD44v6、EGFR and nm23-H1 gene in esophageal squamous cell carcinoma. Methods The protein expressions of CD44v6、EGFR and nm23-H1 were detected in 50 cases of esophageal squamous cell carcinoma with s-p immunohistochemical method. Results The positive rates of CD44v6、EGFR and nm23-H1 in 50 cases of esophageal squamous cell carcinoma were 64%、70% and 50%,respectively. There was a positive relationship between positive expressions of CD44v6 and EGFR degree of differentiation of esophageal squamous cell carcinoma,depth of invasion and metastasis rate of lymph node( P < 0.05 and P < 0.01 ),There was a negative relationship between their positive expression and prognosis of patients( P < 0.05 ). But the significance of the 23-H1 protein exprossion was contrary to that of CD44v6 and EGFR. Conclusion Detecting the expressive levels of CD44v6、EGFR and nm23-H1 proteins simultaneously in esophageal squamous cell cercinoma have cartain reference value for judging malignant degree, invasion and metastasis potential and evaluating prognosis of patients.

关 键 词：食管鳞癌 CD44V6 表皮生长因子受体 NM23-H1基因 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]