肺癌患者化疗前后血清LN、CoIV水平变化及其临床意义  

Serum LN、CoIV change and clinical significance in patients with lung cancer undergone chemotherapy

作　　者：曹锐[1] 李天星[1] 

机构地区：[1]第三军医大学附属大坪医院野战外科研究所肿瘤血液科,重庆400042

出　　处：《肿瘤防治研究》2003年第5期419-420,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨血清LN、CoIV在肺癌患者化疗前后水平变化及其临床价值。方法　应用放射免疫分析法 (RIA)检测 30例肺癌患者化疗前后血清中LN、CoIV水平 ,以 2 0例健康献血员及体检正常者为对照。结果　肺癌组层粘蛋白 (LN)、Ⅳ型胶原 (CoIV)明显高于对照组 ,化疗后有效者 (完全和部分缓解 )血清中LN、CoIV水平明显低于化疗前。结论　动态检测血清LN、CoIV水平对评价疗效有一定价值。Objective To investigate the changes of serum LN, CoIV Level in patients with lung cancer before and after chemotherapy and its clinical implication. Methods The level of serum LN,CoIV were measured by RIA in 30 cases of lung cancer before and after chemotherapy, as compared with 20 cases of normal control subject. Results The Levels of both LN, CoIV were elevated in patients with lung cancer compared to the controls ( P < 0.01 ). The LN, CoIV levels was remarkably reduced in complete remission or partial remission patients after chemotherpy ( P < 0.01 ). Conclusion Determination of serum LN,CoIV may be useful in guiding to chemotherapy.

关 键 词：肺癌 化学治疗 层粘蛋白 IV型胶原 放射免疫分析法 疗效评估 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]