广泛性焦虑障碍与5-羟色胺转运体基因多态性的相关研究  

Association study of serotonin transporter gene polymorphisms and generalized anxiety disorder

作　　者：尤劲松[1] 胡随瑜[1] 张宏耕[2] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,长沙410008 [2]湖南省脑科医院神经症科

出　　处：《中华精神科杂志》2003年第3期132-134,共3页Chinese Journal of Psychiatry

基　　金：国家自然科学基金资助项目 (3 0 0 70 95 3 )

摘　　要：目的　探讨广泛性焦虑障碍与 5 羟色胺转运体 (5 HTT)基因启动子区和内含子 2区两种多态性的相关性。方法　运用聚合酶链反应技术检测 4 7例广泛性焦虑障碍患者 (患者组 )和 90名健康对照者 (对照组 )两种基因多态性的分布频率。结果　患者组启动子区多态性 (5 HTTLPR)的short/short(SS)基因型和short(S)等位基因频率分别为 72 %和 83% ,对照组SS基因型和S等位基因频率分别为 4 9%和 71% ,两组间的差异有显著性 (P <0 0 5 )。内含子 2区数目可变的顺向重复多态性各基因型 (12 / 12 ,12 / 10 ,10 / 10 )频率在患者组中分别为 72 % ,2 6 % ,2 % ,在对照组中分别为 78% ,2 1% ,1% ,两组间的差异无显著性 (P >0 0 5 ) ;等位基因频率比较的差异亦无显著性 (P >0 0 5 )。结论　 5 HTTLPR的SS基因型可能是广泛性焦虑障碍的易感基因之一。Objective To explore the association between generalized anxiety disorder (GAD) and polymorphisms of serotonin transporter (5-HTT). Methods Using a polymerase chain reaction-based technique, polymorphisms of two regions, 5-HTT-linked polymorphic region (5-HTTLPR) and VNTR in intron 2, in serotonin transporter gene were determined in 47 patients with GAD and 90 control subjects, the allelic and genotypic distributions in two groups were compared. Cases and controls were matched for ethnic and geographic origin. Results The frequencies of 5-HTT short/short (SS) genotype and allele S were significantly higher in GAD patients than in controls (72% vs. 49%; 83% vs. 71%; both P< 0.05). However, there was no difference on the distribution of VNTR in intron 2 (12/12, 12/10, 10/10) between patients (72%,26%,2%) and controls (78%,21%,1%). Conclusion The findings support the presence of 5-HTTLPR allele S may increase the risk for generalized anxiety disorder.

关 键 词：广泛性焦虑障碍 5-羟色胺 转运体 基因多态性 启动子 

分 类 号：R749.7[医药卫生—神经病学与精神病学]