生物还原剂的作用机理研究概况  

A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS

作　　者：陈晓晶[1] 金一尊[1] 

机构地区：[1]复旦大学放射医学研究所,上海200032

出　　处：《辐射研究与辐射工艺学报》2003年第2期83-87,共5页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金(30100042)资助

摘　　要：乏氧现象存在于多数实体肿瘤中。生物还原剂是一种具有肿瘤乏氧靶向性的前药,它会在还原性环境中被还原产生具有细胞毒性的代谢物。目前,生物还原剂主要有硝基杂环类、杂环氮氧类、醌类等几类。生物还原剂不仅可以作为放射增敏剂、化学增敏剂,还可以用于基因向导的酶前药治疗(GDEPT)。总之生物还原剂的研究对未来恶性肿瘤治疗有很大的意义。Hypoxia is a feature that exists in most solid tumors. Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species. There are 3 main classes of bio-reductive drugs: the nitro-aromatics, N-oxides and quinones. Recently, bio-reductive drugs were combined with GDEPT for the treatment of cancer, in addition to radiation and the chemotherapeutic agents. Bio-reductive drugs will play a significant role in future cancer therapy.

关 键 词：生物还原剂 作用机理 乏氧现象 基因向导酶前药治疗 恶性肿瘤 硝基杂环化合物 氮氧化合物 醌类化合物 

分 类 号：R730.53[医药卫生—肿瘤] R730.55[医药卫生—临床医学]