含1H-吡唑和噻(二)唑的新型双杂环化合物的合成及其生物活性  

Synthesis and Biological Activity of Novel Bis-heterocyclic Compounds Containing 1H-Pyrazole and Thiazole

作　　者：胡利明[1] 李学恕[1] 陈致远[1] 刘钊杰[1] 

机构地区：[1]华中师范大学有机合成研究所

出　　处：《有机化学》2003年第10期1131-1134,共4页Chinese Journal of Organic Chemistry

基　　金：科技部国家"九五"重点科技攻关 (No .97 563 0 2 0 5)资助项目

摘　　要：以苯肼、乙酰乙酸乙酯和氨基杂环为原料 ,合成了两类含双杂环的新型吡唑甲酰胺衍生物 ,其结构经元素分析、1HNMR ,MS及IR确证 .初步的生物活性测试结果表明 :部分化合物对水稻纹枯病菌、小麦赤霉病菌和苹果轮纹病菌具有良好的抑制效果 .In order to search for novel fungicides with high activity and low toxicity, a series of bis-heterocyclic compounds containing 1H-pyrazole and thiazole were designed and synthesized from phenyl hydrazine, ethyl acetoacetate and aromatic aminoheterolcycles. The structures of all new compounds were confirmed by elemental analysis, H-1 NMR, IR and MS spectra. Preliminary bioassays indicated that some compounds showed fungicidal activity against Pellicularia sasakii, Gibberella zeave and Physalospora piricola.

关 键 词：1H-吡唑 噻二唑 双杂环化合物 农药 合成 生物活性 杀菌活性 

分 类 号：O626[理学—有机化学]