脑性瘫痪仔兔脑组织单胺类神经递质的实验研究  

Study of monoamines in brain with cerebral palsy of newborn rabbits

作　　者：李晓捷[1] 李艳秋 姜志梅[1] 李林[1] 陈秀洁[1] 

机构地区：[1]佳木斯大学康复医学院,佳木斯154002 [2]哈尔滨铁路医院,哈尔滨150001

出　　处：《实用儿科临床杂志》2003年第10期818-820,共3页Journal of Applied Clinical Pediatrics

基　　金：黑龙江省科技攻关项目 (项目编号 :G99C19-16)

摘　　要：目的　检测高胆红素致脑性瘫痪 (脑瘫 )仔兔的海马、皮层、基底神经核、脑干组织中单胺类神经递质含量 ,以探讨单胺类神经递质在脑瘫发病机制中的作用。方法　高胆红素血症致脑瘫仔兔母乳喂养 4 5d ,断头取脑 ,分离所需脑区 ,检测单胺类神经递质并进行病理观察。结果　脑瘫仔兔基底神经核区、脑干区存在单胺类神经递质紊乱 ,与对照组相比 ,实验组基底神经核区多巴胺 (DA)、5 羟色胺 (5 HT)含量降低 ,脑干区去甲肾上腺素 (NE)含量显著降低 ;基底神经核区 5 HT含量与DA含量之间呈正相关。结论　胆红素可选择性地损伤基底神经核区DA、5Objective To discuss the role of monoamines in pathogenesis of cerebral palsy (CP) by measuring the level of monoamines in hippocampus,cerebral cortex,basal ganglia and brain stem in CP newborn rabbits by hyperbilirubinia.Methods To measure the level of monoamines and observe the pathology of newborn CP rabbits,after being fed natural for 45 days and the brain tissues were divided.Results The disorder of monoamines was presented in basal ganglia and brain stem. The level was significantly lower of dopaminum(DA),5-hydroxytry ptamine(5-HT) in basal ganglia and norepine phrine(NE) in brain stem than that in control group.There was positive correlation between DA and 5-HT in basal ganglia. Conclusion Bilirubin may be selectively responsible for damage of the neuron of DA, 5-HT in basal ganglia and NE in brain stem.

关 键 词：脑性瘫痪 动物模型 脑组织 单胺类神经递质 

分 类 号：R742.3[医药卫生—神经病学与精神病学]