中性粒细胞在大鼠肠缺血再灌流导致肺损伤中的作用  

The Role of Polymorphonuclear Neutrophils in Lung Injury Induced by Intestinal Ischemia-reperfusion in Rats

作　　者：何中乾[1] 蒋健[2] 陆一鸣[2] 

机构地区：[1]同济大学附属铁路医院急诊科,上海200072 [2]上海第二医科大学附属瑞金医院急诊科,上海200025

出　　处：《同济大学学报（医学版）》2003年第5期398-399,408,共3页Journal of Tongji University(Medical Science)

摘　　要：目的　探讨肠缺血再灌流引起肺损伤的细胞机制。方法　成年雄性SD大鼠 ,随机分为假手术、肠缺血、肠缺血再灌流三组 ,分别测定各组大鼠肺毛细血管通透性及肺组织髓过氧化酶 (是中性粒细胞的特征酶 )活性、丙二醛含量、过氧化物歧化酶活性。结果　缺血再灌流组肺髓过氧化酶活性、丙二醛含量及毛细血管通透性均高于缺血组及假手术组。结论　中性粒细胞在大鼠肠缺血再灌流致肺损伤中起了重要作用 。Objective To investigate the relationship bet we en lung injury from intestinal ischemia-reperfusion and polymorphonuclear neutr ophils in rats.Methods 24 adult male SD rats were randomly divided into three groups ( n =8),such as sham-operation,intestinal ischemia,and intestina l ischemia-reperfusion (I/R).The pulmonary microvascular permeability and the levels of myeloperoxidase (MPO),malondialdehyde (MDA),superoxide dismutase (SOD) of the lung tissue were checked in each group.Results Comparing with other two groups,the level of MDA, MPO and microvascular permeability in the lung tissue were significantly increas ed in the group of I/R.Conclusion polymorphonuclear neutrophils mediate pulmonar y microvascular injury after intestinal ischemia-reperfusion in rats.

关 键 词：肠缺血再灌流 肺损伤 中性粒细胞 大鼠 

分 类 号：R363[医药卫生—病理学]