单核细胞趋化蛋白-1和基质金属蛋白酶-2在增生性玻璃体视网膜病变增生膜中的表达  

Expression of monocyte chemotactic protein-1 and matrix metalloproteinase-2 in human periretinal membranes of proliferative vitreoretinopathy

作　　者：贾洪真[1] 韩泉洪[1] 惠延年[1] 王琳[1] 杜红俊[1] 崔志利[1] 马吉献[1] 

机构地区：[1]第四军医大学西京医院

出　　处：《眼科新进展》2003年第5期310-313,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号 :30 2 0 0 31 1 )~~

摘　　要：目的　观察单核细胞趋化蛋白 1(monocytechemotacticprotein 1,MCP 1)和基质金属蛋白酶 2 (matrixmetalloproteinase 2 ,MMP 2 )在增生性玻璃体视网膜病变 (PVR)增生膜中的表达。方法　玻璃体手术取出的PVR增生膜 2 4例 ,其中C级膜 11例 ,D级膜13例 ,用免疫组织化学方法检测MCP 1和MMP 2的表达。结果　在全部 2 4例增生膜中 ,MCP 1和MMP 2均有表达 ,MCP 1阳性表达 8例 ,强阳性表达 16例 ;MMP 2阳性表达 7例 ,强阳性表达 17例。结论　MCP 1和MMP 2均存在于PVR增生膜中 ,提示 2者在PVR增生膜的形成和PVR发生发展过程中起重要作用。Objective To investigate the expression of monocyte chemotactic protein 1 (MCP 1) and matrix metalloproteinase 2(MMP 2) in human periretinal membranes of proliferative vitreoretinopathy(PVR).Methods Twenty four specimens of periretinal membranes of PVR( 11 specimens of C grade and 13 of D grade)obtained during vitrectomy were studied by immunohistochemical staining to determine the expression of MCP 1 and MMP 2.Results Immunohistochemical study indicated that MCP 1 and MMP 2 had both a positive staining in all the periretinal membranes of PVR. MCP 1 had a positive staining in 8 of 24 membranes and a strong positive staining in the remaining; MMP 2 had a positive staining in 7 of 24 membranes and a strong positive staining in the rest.Conclusion MCP 1 and MMP 2 both exist in human periretinal membranes of PVR and may play an important role in the development of PVR.

关 键 词：增生性玻璃体视网膜病变 单核细胞趋化蛋白-1 基质金属蛋白酶-2 免疫组 织化学染色 

分 类 号：R774[医药卫生—眼科]