大鼠局灶脑缺血/再灌注损伤后细胞凋亡及TNF-α表达的研究  

A Study of Cell Apoptosis and TNF-α Expressions on Cerebral Ischemic Reperfusion Injury of Rats

作　　者：周刚[1] 刘定华[1] 钱建忠[1] 

机构地区：[1]江苏省江阴市人民医院神经内科,江苏江阴214400

出　　处：《右江民族医学院学报》2003年第5期601-603,共3页Journal of Youjiang Medical University for Nationalities

摘　　要：目的　探讨大鼠局灶脑缺血再灌注损伤与细胞凋亡及肿瘤坏死因子 (TNF -α)表达的关系。方法　用线栓法建立局灶脑缺血再灌注模型 ,观察局灶脑缺血再灌注损伤后细胞凋亡及TNF -α的表达 ,并与假手术对照组作比较。结果　局灶脑缺血再灌注损伤后TNF -α表达及细胞凋亡数均比对照组明显增加 ,神经功能缺陷评分及脑含量水平亦明显上升 ,P均 <0 .0 1。结论　脑缺血再灌注损伤与TNFObjective To study cell apoptosis and TNF-αExpressions in rats with cerebral ischemic reperfusion injury. Methods Made focal cerebral ischemia of MCA animal model induced by cylinder embolization in rats to study of cell apoptosis and TNF-αExpressions in rats with cerebral ischemic reperfusion injury for comparison with the sham-operation control group. Results There were more significantly increases of TNF-α expressions and cell apoptosis than those of the control group and so did the nerve function deficiency grading and brain content level with an average P<0.01. Conclusion There existed a close relationship between cerebral ischemic reperfusion injury and TNF-αExpressions and cell apoptosis.

关 键 词：局灶脑缺血 再灌注损伤 肿瘤坏死因子 细胞凋亡 疾病模型 动物 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R364.1[医药卫生—临床医学]